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Fig. 7 | Human Genomics

Fig. 7

From: Integrative analysis of a novel super-enhancer-associated lncRNA prognostic signature and identifying LINC00945 in aggravating glioma progression

Fig. 7

Epigenomic enhancer profiling defined LINC00945 as a SE-lncRNA. A Enhancer regions of GSCs. Enhancers were ranked by their H3K27ac ChIP-seq signals. Typical enhancers under the curve's inflection were marked in the blue box, while SEs above the inflection point were indicated in the red box. The number of SEs and rank of SE-LINC00945 were presented for each sample. B ChIP-seq profiles of H3K27ac in GSCs and NSCs. C Relative LINC00945 expression in glioma and normal brain tissues from our cohort. D Relative expression of LINC00945 in HEB, LN18, PN12, SF126, SNB19, U251 and T98G cells. E H3K27ac ChIP followed by RT-qPCR identified the SE of LINC00945. The co-immunoprecipitated DNA was amplified by PCR utilizing indicated primer. **p < 0.01, ***p < 0.001. The independent biological experiments were repeated at least three times

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Human Genomics

ISSN: 1479-7364