Skip to main content
Fig. 8 | Human Genomics

Fig. 8

From: Integrative analysis of a novel super-enhancer-associated lncRNA prognostic signature and identifying LINC00945 in aggravating glioma progression

Fig. 8

BRD4 promoted the transcription of LINC00945 via MED1. A–F The correlation of LINC00945 with MED1 (A), BRD4 (B), CDK7 (C), HDAC1 (D), HDAC2 (E), and HDAC3 (F) in the TCGA database, respectively. (G, H) The BRD4 inhibitor lessened the expression of LINC00945 and MED1 in both T98G (G) and U251 (H) cells. I, J The expression of LINC00945 decreased, while the mRNA expression of BRD4 was not affected after knocking down the expression of MED1 by siRNA. K, L The protein expression levels of BRD4 and MED1 were detected by western blot when treated with the siRNA of MED1. *p < 0.05, **p < 0.01, ***p < 0.001, and ns indicates no significance. The independent biological experiments were repeated at least three times

Back to article page

Human Genomics

ISSN: 1479-7364