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Fig. 9 | Human Genomics

Fig. 9

From: Integrative analysis of a novel super-enhancer-associated lncRNA prognostic signature and identifying LINC00945 in aggravating glioma progression

Fig. 9

LINC00945 promotes glioma proliferation in vitro and in vivo. A The overexpression efficiency of LINC00945 was detected by qRT-PCR. B, C CCK8 experiments suggested that overexpression of LINC00945 promoted the proliferative capacity of LN18 (B) and PN12 cells (C). D, E Colony formation assay manifested LINC00945 increased LN18 and PN12 cells tumorigenicity. F–H The mouse xenograft model indicated that LINC00945 facilitated tumor growth in vivo. Images of tumor (F), volume growth curve (G), and tumor weight (H) were shown. (I) The differential expression of LINC00945 in xenograft tumor samples was detected by conducting RT-qPCR. *p < 0.05, **p < 0.01, ***p < 0.001. The independent biological experiments in vitro were repeated at least three times

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Human Genomics

ISSN: 1479-7364