Fig. 1

Clinical variables and miRNA levels at the time of hospital admission, prior to any clinical intervention or treatment, are associated with later ICU admission for COVID-19 patients. A Study design. B Significant Pearson correlations (FDR < 0.05) between 18 factors from electronic health records and ICU admission. C Volcano plots of miRNAs associated with ICU admission. Age and self-reported time from symptom onset to hospital admission were used as covariates in a logistic regression model. miRNAs significant at p < 0.05 are highlighted in blue, and miRNAs significant at p < 0.01 are highlighted in red, with the 5 most significant miRNAs labeled