Fig. 3
From: Systems genetics identifies miRNA-mediated regulation of host response in COVID-19
Expression of numerous miRNAs is genetically controlled by cis-eQTLs. A Manhattan plots showing all cis-eQTLs (defined as an association between a miRNA and a SNP in a 300,000 base pairs window). Points highlighted in pink show cis-eQTLs for miRNAs associated with one of the 8 blood phenotypes The dashed line corresponds to Bonferroni p < 0.05, and all points above the dashed line are significant cis-eQTLs. Labeled points refer to cis-eQTLs with Bonferroni p < 0.05, and some of the top cis-eQTLs are annotated with the e-miRNA. B–G Pairs of violin and fine-mapping plots for cis-eQTLs. The violin plot shows the linear relationships between the number of minor alleles and miRNA expression associated with each genotype. The dashed line corresponds to the linear regression fit, and the p value is stated on the plot. The fine-mapping plot shows all tested SNPs for each miRNA. Points highlighted in blue show e-SNPs significant at Bonferroni p < 0.05. Labeled point shows the top e-SNP for that cis-eQTL. The pink diamond shows the genomic position of the miRNA. B–C cis-eQTL hsa-miR-5189-5p and rs34088055. E–F cis-eQTL rs1256522 and hsa-miR-625-3p. G–H cis-eQTL rs1434282 and hsa-miR-181a-3p