Table 1 Genes associated with Atrial Fibrillation (AF)

1

UBE4B

rs187585530

1

Missense

29892015

2

CASZ1

rs880315; rs284277

1

Intron

29892015; 30061737

3

HSPG2

rs7529220

1

Regulatory region

30061737

4

CELA3B

rs7529220

1

Regulatory region

30061737

5

SCMH1

rs2885697

1

Intronic

30061737

6

AGBL4

rs11590635

1

Intronic

30061737

7

C1orf185

rs146518726

1

Intron

29892015; 30061737

8

KCND3

rs12044963; rs1545300

1p13.2

Intron

29892015/ 28416822; 30061737

9

CASQ2

rs4484922; rs4073778

1

Intron

29892015; 30061737

10

GJA5

rs79187193

1

Upstream gene

29892015; 30061737

11

KCNN3

rs11264280

1

Intergenic

29892015; 30061737

12

PMVK

rs11264280

1

Intergenic

29892015; 30061737

13

METTL11B

rs72700114; rs72700118

1; 1q24

Intergenic

29892015/ 30061737; 28416818

14

KIFAP3

rs72700118

1q24

Intergenic

28416818

15

LINC01142

rs72700114

1

Intergenic

29892015; 30061737

16

GORAB

rs608930

1

Intergenic

29892015

17

PRRX1

rs608930; rs3903239

1; 1q24

Intergenic; 46 kb upstream

29892015; 22544366

18

PPFIA4

rs10753933; rs17461925

1; 1q32.1

Intron

29892015/ 30061737; 28416822

19

NUCKS1

rs4951261; rs4951258

1

Intron

29892015; 30061737

20

NPPA

N/A

1p36.22

N/A

33950154

21

KIF3C

rs6546620; rs7578393

2

Intron

29892015; 30061737

22

XPO1

rs6742276; rs11125871

2

Upstream gene

29892015; 30061737

23

CEP68

rs2540949; rs2540953

2p14; 2

Intronic

28416818/ 29892015/ 30061737; 28416822

24

SLC1A4

rs2540953

2

N/A

28416822

25

SNRNP27

rs10165883; rs6747542

2

Upstream gene

29892015; 30061737

26

REEP1

rs72926475

2

Intergenic

29892015; 30061737

27

KDM3A

rs72926475

2

Intergenic

29892015; 30061737

28

GYPC

rs28387148

2

Intronic

30061737

29

TEX41

rs67969609

2

Intronic

30061737

30

MBD5

rs12992412

2

Intron

29892015

31

WIPF1

rs56181519

2

Intergenic

29892015; 30061737

32

CHRNA1

rs56181519

2

Intergenic

29892015; 30061737

33

TTN

rs35504893; rs2288327

2; 2q31

Intronic

29892015; 28416818/ 30061737/ 33950154

34

TTN-AS1

rs2288327

2q31

Intronic

28416818

35

SPATS2L

rs295114; rs3820888

2

Intron

29892015; 30061737

36

ERBB4

rs35544454

2

Intronic

30061737

37

ANXA4

rs3771537

2p13

Intronic

28416818

38

GMCL1

rs3771537

2p13

Intronic

28416818

39

CAND2

rs6810325; rs4642101; rs7650482

3; 3p25

Intronic

29892015; 25124494; 30061737

40

THRB

rs73032363; rs73041705

3

Intron

29892015; 30061737

41

SCN10A

rs6790396; rs6800541

3; 3p22

Intronic

29892015/ 30061737; 28416818; 33950154

42

SCN5A

N/A

3p22.2

N/A

33950154

43

LRIG1

rs2306272; rs34080181

3

Missense

29892015; 30061737

44

FRMD4B

rs17005647

3

Intronic

30061737

45

EPHA3

rs7632427; rs6771054

3

Downstream gene

29892015; 30061737

46

PHLDB2

rs17490701; rs10804493

3

Intron

29892015; 30061737

47

PPP2R3A

rs1278493

3

Intronic

30061737

48

GNB4

rs4855075; rs7612445

3

Upstream gene

29892015; 30061737

49

XXYLT1

rs60902112

3

Intronic

30061737

50

PAK2

rs9872035

3

Intron

29892015

51

WDR1

rs3822259

4

Upstream gene

29892015

52

PRDM8

rs1458038

4

Intergenic

30061737

53

FGF5

rs1458038

4

Intergenic

30061737

54

SLC9B1

rs3960788; rs10006327

4

Intron

29892015; 30061737

55

PITX2

rs2129977; rs67249485; rs17042171

4

Intergenic

29892015; 30061737; 19597492

56

C4orf32

rs2129977; rs67249485

4

Intergenic

29892015; 30061737

57

CAMK2D

rs55754224; rs6829664

4

Intron

29892015; 30061737

58

ARHGAP10

rs10213171

4

Intron

29892015; 30061737

59

HAND2

rs10520260; rs7698692; rs12648245

4; 4q34.1

Downstream gene

29892015; 28416822; 30061737

60

LOC102467213

rs6596717

5

Intergenic

30061737

61

EFNA5

rs6596717

5

Intergenic

30061737

62

KCNN2

rs716845; rs337711; rs337705

5; 5q22

Intronic

29892015; 28416818; 30061737

63

FBN2

rs2012809

5

Intergenic

30061737

64

SLC27A6

rs2012809

5

Intergenic

30061737

65

WNT8A

rs34750263; rs2967791; rs2040862

5; 5q31

Intergenic; intronic

29892015; 28416818; 30061737

66

NME5

rs34750263; rs2040862

5

Intergenic

29892015; 30061737

67

ARHGAP26

rs174048; rs6580277

5

Intergenic

29892015; 30061737

68

NR3C1

rs174048; rs6580277

5

Intergenic

29892015; 30061737

69

SLIT3

rs12188351

5

Intronic

30061737

70

NKX2-5

rs6882776; rs6891790

5

Upstream gene

29892015; 30061737

71

KLHL3

rs2967791

5q31

Intronic

28416818

72

FAM13B

rs2967791

5q31

Intronic

28416818

73

ATXN1

rs73366713

6

Intron

29892015; 30061737

74

KDM1B

rs34969716

6

Intron

29892015; 30061737

75

C6orf1

rs1307274

6

Regulatory region

29892015

76

NUDT3

rs1307274

6

Regulatory region

29892015

77

CDKN1A

rs3176326

6

Intron

29892015; 30061737

78

CGA

rs6907805; rs2031522

6

Intergenic

29892015; 30061737

79

ZNF292

rs6907805; rs2031522

6

Intergenic

29892015; 30061737

80

GOPC

rs210632

6

Downstream gene

29892015

81

SLC35F1

rs17079881; rs4946333; rs89107; rs3951016

6; 6q22; 6q22

Intronic

29892015;28416818; 28416818; 30061737

82

PLN

rs4946333; rs89107

6q22

Intronic

28416818; 28416818

83

GJA1

rs13191450; rs13216675; rs13195459

6; 6q22

Intergenic

29892015; 25124494; 30061737

84

HSF2

rs13191450; rs13195459

6

Intergenic

29892015; 30061737

85

LINC00326

rs12208899

6

Intergenic

29892015

86

EYA4

rs12208899

6

Intergenic

29892015

87

UST

rs117984853

6

Downstream gene

29892015; 30061737

88

SUN1

rs11768850

7

Intron

29892015

89

DGKB

rs55734480

7

Intron

29892015; 30061737

90

CREB5

rs6462078; rs6462079

7

Intron

29892015; 30061737

91

GTF2I

rs74910854; rs35005436

7

Intron

29892015; 30061737

92

CDK6

rs11773884; rs56201652

7

Intron

29892015; 30061737

93

COG5

rs62483627

7

Intron

29892015

94

CAV1

rs11773845; rs3807989

7; 7q31

Intronic

29892015/ 30061737; 22544366

95

OPN1SW

rs55985730

7

Upstream gene

29892015; 30061737

96

KCNH2

rs7789146

7

Intron

29892015; 30061737

97

LINC00208

rs35620480

8

Regulatory region

30061737

98

GATA4

rs35620480

8

Regulatory region

30061737

99

ASAH1

rs7508

8; 8p22

3' utr

29892015; 28416818; 30061737

100

PCM1

rs7508

8p22

3′ utr

28416818

101

XPO7

rs7846485; rs7834729

8

Intron

29892015; 30061737

102

FBXO32

rs62521286

8

Intron

29892015; 30061737

103

MTSS1

rs35006907

8

Regulatory region

29892015

104

LINC00964

rs35006907

8

Regulatory region

29892015

105

MIR30B

rs7460121

8

Downstream gene

29892015

106

PTK2

rs6993266; rs6994744

8

Intron

29892015; 30061737

107

SLC24A2

rs4977397

9

Intergenic

29892015

108

MLLT3

rs4977397

9

Intergenic

29892015

109

C9orf3

rs4385527; rs10821415

9

Intron

29892015; 30061737

110

C9orf3 (FBP1)

rs10821415

9q22

Intronic

22544366

111

C9orf3 (FBP2)

rs10821415

9q22

Intronic

22544366

112

ZNF462

rs4743034

9

Intron

29892015

113

PSMB7

rs10760361

9

Upstream gene

29892015

114

LHX3

rs2274115

9

Intronic

30061737

115

REEP3

rs7919685; rs12245149

10

Intron

29892015; 30061737

116

SIRT1

rs7096385

10

Intronic

30061737

117

SYNPO2L

rs60212594; rs10824026

10; 10q22

Intron; 5 kb upstream

29892015/ 30061737; 22544366

118

MYOZ1

rs10824026

10q22

20 kb upstream

22544366

119

C10orf11

rs11001667; rs10458660

10

Intron

29892015; 30061737

120

C10orf76

rs1044258

10

3' utr

29892015

121

NEURL

rs11598047; rs12415501; rs6584555

10; 10q24; 10q24

Intronic

29892015/ 30061737; 25124494; 25124494

122

RBM20

rs10749053

10

Intronic

30061737

123

SH3PXD2A

rs35176054, rs202011870; rs2047036

10q24; 10q24; 10q24.33

Intronic

28416818; 28416818; 28416822

124

NEBL

rs2296610

10p12

Missense variant

28416822

125

NAV2

rs1822273; rs10741807

11

Intron

29892015; 30061737

126

SORL1

rs949078; rs4935786

11

Intergenic

29892015; 30061737

127

MIR100HG

rs949078; rs4935786

11

Intergenic

29892015; 30061737

128

KCNJ5

rs76097649; rs75190942

11; 11q24

Upstream gene; intronic

29892015/ 30061737; 28416818

129

KCNQ1

N/A

11p15.5-p15.4

N/A

33950154

130

KCNJ11

N/A

11p15.5

N/A

33950154

131

LINC00477

rs10842383; rs4963776

12

Intergenic

29892015; 30061737

132

BCAT1

rs10842383; rs4963776

12

Intergenic

29892015; 30061737

133

SSPN

rs113819537; rs17380837

12

Upstream gene

29892015; 30061737

134

PKP2

rs12809354

12

Intron

29892015; 30061737

135

NACA

rs7978685; rs2860482

12

Downstream gene

29892015; 30061737

136

BEST3

rs35349325; rs71454237

12

Upstream gene

29892015; 30061737

137

KRR1

rs11180703; rs12426679

12

Intergenic

29892015; 30061737

138

PHLDA1

rs11180703; rs12426679

12

Intergenic

29892015; 30061737

139

TBX5

rs883079; rs10507248

12; 12q24

3' utr; intronic

29892015/ 30061737; 25124494

140

CUX2

rs6490029

12q24

Intronic

25124494

141

TBX5-AS1

rs12810346

12

Intergenic

29892015

142

TBX3

rs12810346

12

Intergenic

29892015

143

HIP1R

rs10773657

12

Intronic

30061737

144

DNAH10

rs12298484

12

Intron

29892015

145

FBRSL1

rs6560886

12

Intronic

30061737

146

SOX5

rs11047543

12p12

Intergenic

28416818

147

CACNA1C

N/A

12p13.33

N/A

33950154

148

LINC00540

rs9580438; rs9506925

13

Intergenic

29892015; 30061737

149

BASP1P1

rs9580438; rs9506925

13

Intergenic

29892015; 30061737

150

CUL4A

rs35569628

13

Intronic

30061737

151

MYH7

rs28631169; rs422068

14

Intron

29892015; 30061737

152

AKAP6

rs2145587; rs11156751

14

Intron

29892015; 30061737

153

SNX6

rs73241997

14

Intergenic

29892015; 30061737

154

CFL2

rs73241997

14

Intergenic

29892015; 30061737

155

SYNE2

rs2738413; rs1152591

14; 14q23

Intronic

29892015/ 30061737; 22544366

156

DPF3

rs74884082

14

Intronic

30061737

157

LRRC74

rs10873299; rs10873298

14

Intergenic

29892015; 30061737

158

IRF2BPL

rs10873299; rs10873298

14

Intergenic

29892015; 30061737

159

MYH6

N/A

14q11.2

N/A

33950154

160

GCOM1

rs147301839

15

Missense

30061737

161

USP3

rs62011291; rs7170477

15

Intron

29892015; 30061737

162

TLE3

rs12591736

15

Intergenic

29892015

163

UACA

rs12591736

15

Intergenic

29892015

164

HCN4

rs74022964; rs7164883

15; 15q24

Intergenic; intronic

29892015/ 30061737; 22544366

165

REC114

rs74022964

15

Intergenic

29892015; 30061737

166

LINC00927

rs12908004

15

Intron

29892015; 30061737

167

ARNT2

rs12908004

15

Intron

29892015; 30061737

168

IGF1R

rs12908437; rs4965430

15

Intron

29892015; 30061737

169

RPS2

rs2286466; rs140185678

16

Synonymous

29892015; 30061737

170

ZFHX3

rs2359171; rs2106261

16; 16q22

Intronic

29892015/ 30061737; 19597492

171

YWHAE

rs7225165

17

Intergenic

30061737

172

CRK

rs7225165

17

Intergenic

30061737

173

POLR2A

rs8073937; rs9899183

17

Intergenic

29892015; 30061737

174

TNFSF12

rs8073937; rs9899183

17

Intergenic

29892015; 30061737

175

MYOCD

rs72811294

17

Intron

29892015; 30061737

176

ZPBP2

rs11658278

17

Intronic

30061737

177

MAPT

rs242557

17

Intron

29892015

178

GOSR2

rs76774446; rs1563304

17

Downstream gene

29892015; 30061737

179

KCNJ2

rs7219869

17

Intergenic

29892015

180

CASC17

rs7219869

17

Intergenic

29892015

181

CYTH1

rs12604076

17

Intronic

30061737

182

SMAD7

rs9953366

18

Intron

29892015; 30061737

183

MEX3C

rs8088085

18

Intronic

30061737

184

CASC20

rs2145274

20

Regulatory region

29892015

185

BMP2

rs2145274

20

Regulatory region

29892015

186

C20orf166

rs7269123

20

Intron

29892015

187

LOC100506385

rs2834618

21

Intron

29892015; 30061737

188

TUBA8

rs465276; rs464901

22

Intron

29892015; 30061737

189

MYO18B

rs133902

22

Splice region

30061737

190

KCNE5

N/A

Xq23

N/A

33950154