Table 2 Article details about genes associated with Atrial Fibrillation (AF)

28416818

12

GWAS:

AF = 17,931

Referents = 115,142

ExWAS, RVAS:

AF = 22,346

Referents = 132,086

Multi-ethnic: European, Asian, African-American, Brazilian, Hispanic

hypertension, myocardial infarctions, diabetes mellitus, heart failure

P < 5E − 8 (GWAS); P < 1.04E − 6 (ExWAS); P = 3.3E − 11 (RVAS)

WGS, WES

SNPtest, ProABE, and PLINK, seqMeta package of R statistical power

25,124494

5

GWAS:

European:

AF = 6,691

Referents = 17,142

Japanese:

AF = 8,373

Referents = 20,540

European, Japanese

diabetes, myocardial infarctions, congestive heart failure

P < 5E5

N/A

N/A

33950154

9

Male = 132

Female = 95

African, Hispanic

hypertension, type II diabetes, congestive heart failure, coronary artery disease, valve heart disease, left ventricular ejection fraction, vascular disease

P ≤ 5.0E-2

Illumina NextSeq500, Sanger sequencing

N/A

19597492

1

GWAS:

European:

AF = 896

Referents = 15,768

European-American:

AF = 2,517

Referents = 21,337

European, European-American

prevalent AF after CKD diagnosis, incident AF after CKD diagnosis

P = 2.3E − 7

N/A

ProbABEL, R ProbABEL, PLINK, R R, version 2.7 PLINK, R Mach2QTL GenABEL + PLINK

22544366

6

GWAS:

AF = 6,707

Controls = 52,426

European, Japanese

hypertension, diabetes, heart failure, myocardial infarction

P < 5E − 8

N/A

ProbABEL, R, PLINK, R packages kinship, GEE, COXPH, Mach2QTL GenABEL + PLINK, GRIMP, QUICKTEST v0.94, PLATO, R, version 2.10

28416822

6

GWAS:

AF = 8,180

Controls = 28,612

Japanese

diabetes, myocardial infarction, heart failure

P < 5.0E − 8

N/A

N/A

29892015

97 (67 novel)

GWAS:

AF = 65,446

Multi-ethnic: European, Japanese,

African-American, Brazilian, Hispanic

hypertension, diabetes mellitus, myocardial infarction, heart failure

P < 1E − 8

RNA-seq

ProbABEL, SNPTEST, FAST, mach2dat, R, EPACTS, Hail, and PLINK

30061737

111 (80 novel)

GWAS:

AF = 60,620

Controls = 970,216

Multi-ethnic

N/A

P < 5E − 8

N/A

N/A