Genomic approaches to identify and investigate genes associated with atrial fibrillation and heart failure susceptibility

Table 5 List of common genes associated with atrial fibrillation (AF) and heart failure (HF)

#	Gene	Disease	Chromosome	HF SNP rsID	AF SNP rsID	Gene Location (HF)	Gene Location (AF)	Gene Role
1	SYNPO2L	HF, AF	10	rs4746140	rs60212594; rs10824026	intergenic	intron; 5 kb upstream	Cardiac development: expressed in skeletal and cardiac muscle, localize to the Z-disk and interact with numerous other proteins
2	TTN	HF, AF	2	N/A	rs35504893; rs2288327	N/A	intronic	Sarcomere assembly, stretch sensing and signaling, passive stiffness adjustment; encodes for a large sarcomeric protein known as titin
3	MTSS1	HF, AF	8	N/A	rs35006907	N/A	regulatory region	Cytoskeleton signaling pathway and encodes a scaffold protein which regulates actin dynamics
4	SCN5A	HF, AF	3	rs1805126	3 variants	coding	N/A	Associated w/expression of MYOZ1 and SYNPO2L encoding 2 alpha-actinin-binding Z-disk cardiac proteins; encodes protein for cardiac sodium channel
5	PITX2	HF, AF	4	rs17042102	rs2129977	intergenic	intergenic	Encodes a transcription factor
6	KLHL3	HF, AF	5	rs11745324	rs2967791	intronic	intronic	A negative regulator of the thiazide-sensitive Na + Cl- cotransporter (SLC12A3) in the distal nephron
7	AGAP5	HF, AF	10	rs4746140	N/A	intergenic	N/A	Associated w/expression of MYOZ1 and SYNPO2L encoding 2 alpha-actinin-binding Z-disk cardiac proteins

This table includes information about genes, disease, SNPs, chromosomes, location relative to gene, and gene role

ISSN: 1479-7364