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Fig. 2 | Human Genomics

Fig. 2

From: Clinical prognosis and related molecular features of hepatitis B-associated adolescent and young adult hepatocellular carcinoma

Fig. 2

Unique differentially expressed mRNAs of HBV-AYA HCC patients and the functional analysis. A, B volcano plot of differentially expressed mRNAs in the AYA group (A) and the elderly group (B); C venn diagram of differentially expressed mRNAs between the AYA and elderly groups. The part in the red box is the young unique differentially expressed genes; D heatmap of AYA unique differentially expressed mRNAs; E bubble plot of enriched pathways of the differentially expressed genes; F, H GSEA of all genes in the AYA group. The top plot is based on the KEGG database (F), and the bottom plot is based on the Reactome database (H); G, I age-related GSEA analysis of 241 genes. The above 6 are based on KEGG (G), and the rest are based on Reactome (I). The p value of the pathway was < 0.05. YT, tumor sample of the AYA group; YNT, paratumor sample of the AYA group; OT, tumor sample of the elderly group; ONT, paratumor sample of the elderly group; p.adjust, tested by hypergeometric distribution, adjusted by the Benjamini and Hochberg method

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Human Genomics

ISSN: 1479-7364