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Fig. 5 | Human Genomics

Fig. 5

From: Clinical prognosis and related molecular features of hepatitis B-associated adolescent and young adult hepatocellular carcinoma

Fig. 5

MPI network construction of metabolism-related genes and identification of two TCGA HCC subtypes. A The network in the upper left corner is the MPI network of AYA unique differential metabolism-related genes, the yellow dot is the gene, and the green dot is the metabolite. The network in the upper right corner is the PPI network of differentially downregulated genes, with the yellow dot being a metabolism-related gene and the green dot being another downregulated gene, below which 12 hub genes were screened by the MCC algorithm. The network below is the MPI network of 5 hub metabolism-related genes; B PCA of TCGA-HCC tumor samples based on 5 hub genes. Points are colored according to the consensus clustering results, and the two subtypes can be exactly separated by the line PC1 = PC2; C Kaplan–Meier plot of the differential prognosis between the two subtypes; D Significant differences between the two subtypes in the age and 5 hub genes. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 and ns for not significant

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Human Genomics

ISSN: 1479-7364