Fig. 7

ceRNA network establishment of HBV-AYA HCC. A Heatmap of AYA unique differentially expressed lncRNAs; B heatmap of AYA unique differentially expressed miRNAs; C KEGG functional analysis results of target genes under trans-regulation of lncRNAs. D the KEGG enrichment bubble diagram of miRNA target differentially expressed genes; E KEGG pathway prediction of differentially expressed miRNAs based on the TarBase database; F the lncRNA‒miRNA‒mRNA ceRNA network constructed with the differentially expressed lncRNAs, miRNAs and mRNAs. The line between the two columns indicates the existence of a regulatory relationship, and the longitudinal width of each RNA frame represents its importance in the network; G the relationship network between the enriched KEGG pathways and the corresponding differential genes. The yellow dot is the pathway, the grey dot is the gene, and the size of the yellow dot represents the number of genes enriched; H the RT‒qPCR results of CDC42SE1 and hsa-miR-378a-5p. *p < 0.05, **p < 0.01 and ns for not significant