Fig. 2

Predicted EVOO phytochemicals targeting dysregulated pathways in AD. The targeted pathways include: Blue denotes (Olfactory Transduction), violet denotes (Alzheimer’s disease), green denotes (Insulin Signaling), greenish blue denotes (Phosphatidylinositol Signaling), and orange denotes (Vascular Smooth Muscle Contraction). The key protein-encoding genes associated with a specific pathway (Additional File 5) are assigned the same color for easy identification. The size of each gene/protein node is proportional to how often the related pathway is targeted by the model EVOO phytochemicals listed in Table 1. Nodes associated with EVOO phytochemicals and their interactions with protein-encoding genes from AD dysregulated pathways are highlighted in brown. Only experimentally validated protein–protein interactions (STRING score greater than 800) are emphasized