From: Smoking-related dysregulation of plasma circulating microRNAs: the Rotterdam study
miRNA | Cessation < 5 years (N = 83) | Cessation > 5 and < 15 years (N = 161) | Cessation > 15 years (N = 535) | ||||||
---|---|---|---|---|---|---|---|---|---|
Beta | SE | P-value | Beta | SE | P-value | Beta | SE | P-value | |
miR-326 | 0.239 | 0.0711 | 8.25 × 10–04 | 0.206 | 0.0555 | 2.23 × 10–04 | 0.132 | 0.0396 | 8.65 × 10–04 |
miR-6769b-3p | − 0.0903 | 0.0275 | 1.10 × 10–03 | − 0.0906 | 0.0218 | 3.84 × 10–05 | − 0.0635 | 0.0148 | 1.89 × 10–05 |
miR-10b-5p | − 0.118 | 0.0464 | 1.14 × 10–02 | − 0.194 | 0.0428 | 7.34 × 10–06 | − 0.148 | 0.026 | 1.65 × 10–08 |
miR-6845-5p | − 0.134 | 0.0552 | 1.55 × 10–02 | − 0.131 | 0.0425 | 2.24 × 10–03 | − 0.139 | 0.0302 | 4.70 × 10–06 |
miR-30a-3p | − 0.14 | 0.0585 | 1.73 × 10–02 | − 0.0845 | 0.0435 | 5.23 × 10–02 | − 0.131 | 0.0322 | 5.17 × 10–05 |
miR-6738-5p | − 0.134 | 0.057 | 1.95 × 10–02 | − 0.126 | 0.0422 | 2.92 × 10–03 | − 0.144 | 0.0357 | 6.16 × 10–05 |
miR-30a-5p | − 0.0632 | 0.0283 | 2.57 × 10–02 | − 0.101 | 0.0226 | 1.03 × 10–05 | − 0.0855 | 0.0161 | 1.44 × 10–07 |
miR-10a-5p | − 0.101 | 0.0472 | 3.21 × 10–02 | − 0.161 | 0.0389 | 3.99 × 10–05 | − 0.125 | 0.0278 | 7.22 × 10–06 |
miR-4505 | − 0.0608 | 0.0296 | 4.03 × 10–02 | − 0.0812 | 0.0237 | 6.54 × 10–04 | − 0.0425 | 0.0168 | 1.13 × 10–02 |
miR-6821-5p | − 0.125 | 0.0647 | 5.49 × 10–02 | − 0.182 | 0.0505 | 3.44 × 10–04 | − 0.174 | 0.0359 | 1.39 × 10–06 |
miR-27a-3p | − 0.105 | 0.0571 | 6.63 × 10–02 | − 0.157 | 0.0454 | 5.84 × 10–04 | − 0.173 | 0.0323 | 1.13 × 10–07 |
miR-126-5p | − 0.105 | 0.0616 | 8.98 × 10–02 | − 0.17 | 0.0495 | 6.44 × 10–04 | − 0.134 | 0.0359 | 1.93 × 10–04 |
miR-149-3p | − 0.0893 | 0.0527 | 9.06 × 10–02 | − 0.122 | 0.0417 | 3.73 × 10–03 | − 0.148 | 0.0297 | 7.24 × 10–07 |
miR-29b-3p | − 0.0561 | 0.0352 | 1.12 × 10–01 | − 0.158 | 0.0304 | 3.02 × 10–07 | − 0.125 | 0.0205 | 1.41 × 10–09 |
miR-23a-3p | − 0.0849 | 0.0547 | 1.21 × 10–01 | − 0.0807 | 0.0436 | 6.50 × 10–02 | − 0.136 | 0.031 | 1.29 × 10–05 |
miR-195-5p | − 0.0673 | 0.0455 | 1.40 × 10–01 | − 0.0932 | 0.0356 | 9.18 × 10–03 | − 0.0956 | 0.0258 | 2.22 × 10–04 |
miR-1285-5p | 0.108 | 0.0754 | 1.53 × 10–01 | 0.0646 | 0.0614 | 2.94 × 10–01 | 0.207 | 0.0426 | 1.37 × 10–06 |
miR-1237-5p | − 0.091 | 0.0641 | 1.56 × 10–01 | − 0.126 | 0.05 | 1.18 × 10–02 | − 0.185 | 0.0341 | 7.15 × 10–08 |
miR-1915-3p | 0.0943 | 0.0685 | 1.69 × 10–01 | − 0.179 | 0.053 | 7.97 × 10–04 | − 0.206 | 0.0366 | 2.49 × 10–08 |
miR-6869-5p | 0.0712 | 0.0519 | 1.71 × 10–01 | − 0.0806 | 0.0403 | 4.61 × 10–02 | − 0.134 | 0.0294 | 6.06 × 10–06 |
miR-8069 | 0.0768 | 0.0614 | 2.11 × 10–01 | − 0.116 | 0.0481 | 1.59 × 10–02 | − 0.126 | 0.0313 | 6.25 × 10–05 |
miR-6085 | 0.0996 | 0.0796 | 2.12 × 10–01 | − 0.226 | 0.0616 | 2.72 × 10–04 | − 0.212 | 0.0425 | 7.59 × 10–07 |
miR-93-5p | 0.0629 | 0.0517 | 2.24 × 10–01 | 0.105 | 0.0401 | 9.25 × 10–03 | 0.0949 | 0.0293 | 1.25 × 10–03 |
miR-654-5p | 0.0786 | 0.0658 | 2.32 × 10–01 | − 0.14 | 0.0441 | 1.55 × 10–03 | − 0.135 | 0.0324 | 3.39 × 10–05 |
miR-27b-3p | 0.0486 | 0.041 | 2.36 × 10–01 | − 0.159 | 0.0343 | 4.76 × 10–06 | − 0.157 | 0.0233 | 3.00 × 10–11 |
miR-1913 | 0.0425 | 0.0359 | 2.37 × 10–01 | 0.0776 | 0.0276 | 5.20 × 10–03 | 0.059 | 0.0202 | 3.57 × 10–03 |
miR-126-3p | − 0.0543 | 0.0466 | 2.45 × 10–01 | − 0.124 | 0.0367 | 7.85 × 10–04 | − 0.107 | 0.0259 | 4.02 × 10–05 |
miR-1914-5p | 0.0605 | 0.0534 | 2.57 × 10–01 | 0.0766 | 0.0406 | 5.96 × 10–02 | 0.0985 | 0.0288 | 6.47 × 10–04 |
miR-23b-3p | − 0.0538 | 0.0478 | 2.61 × 10–01 | − 0.128 | 0.0385 | 9.11 × 10–04 | − 0.154 | 0.0259 | 3.83 × 10–09 |
miR-150-5p | − 0.0796 | 0.0709 | 2.62 × 10–01 | − 0.231 | 0.0543 | 2.48 × 10–05 | − 0.203 | 0.0365 | 3.60 × 10–08 |
miR-100-5p | − 0.0541 | 0.0511 | 2.90 × 10–01 | − 0.178 | 0.0416 | 2.09 × 10–05 | − 0.135 | 0.0286 | 3.02 × 10–06 |
miR-29a-3p | − 0.0372 | 0.0392 | 3.44 × 10–01 | − 0.134 | 0.0317 | 2.82 × 10–05 | − 0.116 | 0.0207 | 3.37 × 10–08 |
let-7e-5p | 0.0332 | 0.0464 | 4.74 × 10–01 | − 0.0874 | 0.0383 | 2.28 × 10–02 | − 0.125 | 0.0275 | 6.26 × 10–06 |
miR-146b-5p | − 0.015 | 0.0314 | 6.34 × 10–01 | − 0.0503 | 0.0252 | 4.67 × 10–02 | − 0.0741 | 0.018 | 4.14 × 10–05 |
miR-342-3p | − 0.0174 | 0.0388 | 6.55 × 10–01 | − 0.102 | 0.0314 | 1.24 × 10–03 | − 0.125 | 0.0249 | 5.89 × 10–07 |
miR-30b-5p | 0.0134 | 0.0369 | 7.16 × 10–01 | − 0.0796 | 0.0306 | 9.68 × 10–03 | − 0.0723 | 0.0212 | 6.81 × 10–04 |
miR-92a-3p | 0.0156 | 0.0457 | 7.34 × 10–01 | 0.0809 | 0.0361 | 2.53 × 10–02 | 0.0917 | 0.0266 | 5.93 × 10–04 |
let-7c-5p | 0.00796 | 0.0302 | 7.92 × 10–01 | − 0.0885 | 0.0265 | 8.98 × 10–04 | − 0.0663 | 0.0177 | 1.87 × 10–04 |
miR-4632-5p | − 0.00905 | 0.0820 | 9.12 × 10–01 | − 0.125 | 0.0641 | 5.18 × 10–02 | − 0.18 | 0.0457 | 8.56 × 10–05 |
miR-155-5p | − 0.00327 | 0.0596 | 9.56 × 10–01 | − 0.15 | 0.0488 | 2.20 × 10–03 | − 0.121 | 0.035 | 5.77 × 10–04 |
miR-486-5p | 0.00327 | 0.0638 | 9.59 × 10–01 | 0.16 | 0.0495 | 1.32 × 10–03 | 0.154 | 0.0366 | 2.79 × 10–05 |