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Table 5 Comparison of bleeding events among genotypes

From: The impact of ABCB1, CYP3A4/5 and ABCG2 gene polymorphisms on rivaroxaban trough concentrations and bleeding events in patients with non-valvular atrial fibrillation

SNP

Genotype

Bleeding

No-bleeding

P

ABCB1

rs1045642 (A > G)

AA

1

14

0.609

AG

10

40

 

GG

5

25

 

ABCB1

rs1128503 (A > G)

AA

4

31

0.484

AG

11

39

 

GG

1

9

 

ABCB1

rs4148738 (C > T)a

CC

3

12

1.000

CT

9

42

 

TT

4

25

 

ABCB1

rs4728709 (G > A)a

GG

13

53

0.581

GA

3

20

 

AA

0

2

 

CYP3A4

rs2242480(C > T)

CC

6

33

0.822

CT

9

36

 

TT

1

6

 

CYP3A4

rs4646437(G > A)a

GG

11

49

0.793

GA

4

24

 

AA

1

2

 

CYP3A5

rs776746

(T > C)

TT

1

6

0.827

TC

8

32

 

CC

6

35

 

ABCG2

rs2231137(C > T)

CC

6

36

0.244

CT

7

34

 

TT

3

5

 

ABCG2

rs2231142(G > T)

GG

8

37

0.852

GT

6

31

 

TT

2

7

 
  1. aBecause it does not meet the requirements of the R*C chi-square test, the homozygous mutations and heterozygous mutations were combined for analysis
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Human Genomics

ISSN: 1479-7364