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Fig. 3 | Human Genomics

Fig. 3

From: Pharmacovariome scanning using whole pharmacogene resequencing coupled with deep computational analysis and machine learning for clinical pharmacogenomics

Fig. 3

Homology modelling for three selected pharmacovariants in deep computational analysis. Close view of three damaging variants with potential influence on changing protein structure and functions in selected genes: A Wild type POLG protein, produced using 3IKM as the template, close view of Pro587. B Mutated POLG (p. Pro587Leu) protein model, produced using 3IKM as the template. C Wild type annexin A11 protein modelled using 6TU2 as the template, close view of Arg230. D Mutated annexin A11 protein (p. Arg230Cys) modelled using 6TU2 as the template. E Wild type EC 26 domain of cadherin-23 protein modelled using mouse cadherin-23 structure (5WJM) as the template, close view of Gly2771. F Mutated EC 26 domain of cadherin-23 protein (p. Gly2771Ser), modelled using mouse cadherin-23 structure (5WJM) as the template

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Human Genomics

ISSN: 1479-7364