From: Landscape of germline pathogenic variants in patients with dual primary breast and lung cancer
Characteristics (n = 55) | n (%) | |
---|---|---|
Ethnicity | ||
Chinese | 50 (90.9) | |
Others | 5 (9.1) | |
Smoking status | ||
Never-smoker | 52 (94.5) | |
Smoker | 3 (5.5) | |
Temporal occurrence of lung and breast cancer diagnosis | ||
Lung cancer occurred first | 5 (9.1) | |
Breast cancer occurred first | 38 (69.1) | |
Synchronous (within 6 months) | 12 (21.8) | |
Family cancer history (any primary) | ||
First degree | 27 (49.1) | |
Second degree | 4 (7.3) | |
No known history | 24 (43.6) | |
Family history of breast and/or lung cancer | ||
First degree | 8 (14.5) | |
Second degree | 2 (3.6) |
Breast cancer | Lung cancer | ||
---|---|---|---|
Diagnosis year | 1976–2018 | Diagnosis year | 2005–2018 |
Median age, years (range) | 55 (34–81) | Median age, years (range) | 65 (48–78) |
Histology | n (%) | Histology | n (%) |
Ductal carcinoma in situ (DCIS) | 5 (9.1) | Adenocarcinoma (ADC) | 44 (80) |
Infiltrating ductal carcinoma (IDC) | 33 (60) | Neuroendocrine carcinoma | Â |
Infiltrating lobular carcinoma (ILC) | 4 (7.3) | Carcinoid | 2 (3.6) |
DCIS + DCIS (bilateral) | 1 (1.8) | SCLC | 3 (5.5) |
IDC + DCIS (bilateral) | 2 (3.6) | Undifferentiated | 1 (1.8) |
IDC + ILC (bilateral) | 2 (3.6) | Lymphoepithelioma-like carcinoma (LELC) | 1 (1.8) |
IDC + unknown subtype (bilateral) | 1 (1.8) | ADC + Carcinoid (bilateral, synchronous) | 1 (1.8) |
Mucinous adenocarcinoma | 3 (5.5) | ADC + ADC (bilateral, synchronous) | 1 (1.8) |
Subtype not specified (NOS) | 4 (7.3) | ADC + ADC (same side, synchronous) | 2 (3.6) |
Staginga | Stagingb | ||
0 | 6 (10.9) | 0 | 0 (0.0) |
I/II | 44 (80.0) | I/II | 26 (47.3) |
III | 4 (7.3) | III | 7 (12.7) |
IV | 1 (1.8) | IV | 22 (40.0) |
Hormone and HER2 statusc | EGFR status (Adenocarcinoma only, n = 49) | ||
ER | Not tested | 4 (8.2) | |
Positive | 36 (65.4) | Tested | 45 (91.8) |
Negative | 10 (18.2) | Mutant | 33 (73.3*) |
Not tested/unknown | 9 (16.4) | Exon19 del | 19 (57.6^) |
PR | L858R | 11 (33.3^) | |
Positive | 30 (54.5) | Others | 3 (9.1^) |
Negative | 15 (27.3) | Wild type | 12 (26.7*) |
Not tested/unknown | 10 (18.2) | Â | Â |
HER2 | Â | Â | |
Positive | 4 (7.3) | Â | Â |
Negative | 28 (50.9) | Â | Â |
Not tested/unknown/equivocal | 23 (41.8) | Â | Â |