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Fig. 1 | Human Genomics

Fig. 1

From: CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes

Fig. 1

Overview of the bioinformatic pipeline to identify non-coding genes associated with cardiovascular diseases. Step 1: SNPs for 6 different cardiac diseases were collected from the NHGRI-EBI GWAS catalog. Step 2: We used existing transcription factor binding models to filter regulatory SNPs (rSNPs), that are predicted to have an impact on transcription factor binding sites (TFBS). Step 3: rSNPs are linked to putative target genes using enhancer-gene links. For each step the number of SNPs or genes separated for coding and non-coding for each disease is given per row

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Human Genomics

ISSN: 1479-7364