Fig. 3
From: CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes
Disease enrichment analysis based on the protein coding genes co-expressed with GWAS-associated non-coding genes. A We sought to identify co-expressed protein-coding genes (PCGs, triangles) for each non-coding gene (NCG, circle) using a large dataset of RNA-seq samples from GTEx top correlated protein-coding genes are tested for an enrichment of previous indications with a cardiovascular disease. B Bar plot visualizing the number of non-coding and co-expressed protein-coding genes per GWAS (row). C Dot plot showing enriched cardiovascular phenotypes from DisGeNET (x-axis) for the top 10 co-expressed protein-coding genes of the associated non-coding genes separated per GWAS (y-axis). The dot coloring represents whether a phenotype is significantly enriched (FDR ≤ 0.05) and the dot size is relative to the FDR