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Fig. 2 | Human Genomics

Fig. 2

From: Developing neural network diagnostic models and potential drugs based on novel identified immune-related biomarkers for celiac disease

Fig. 2

Identification of the hub immune genes (HIGs). A The volcano plot shows the differentially expressed genes (DEGs) in celiac disease retrieved from GSE11501. B Venn plot shows the intersection of DEGs with immune-related genes. C Heatmap shows the overall landscape of 58 differentially expressed immune-related genes between healthy control and celiac disease. D LASSO coefficient profiles of the indicated differentially expressed immune-related genes (left panel). After cross-validation for tuning parameter selection, 15 candidate HIGs were identified (right panel). E SVM–RFE algorithm identified 33 candidate HIGs with an accuracy of 0.932 (left panel) and an error of 0.0681 (right panel). F RandomForest algorithm identified 10 candidate HIGs. RandomForest error rate versus the number of classification trees (left panel) and gene importance scores (right panel). G Venn plot shows the overlapped candidate HIGs

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Human Genomics

ISSN: 1479-7364