Table 4 Risk of toxicity according to common polymorphisms of DPYS (all variants) and PPARD (variants in the 3’UTR/5’UTR)
|  | Cumulative toxicity | Acute toxicity (Cycle ≤ 1) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Yes (n = 82) | No (n = 96) | OR (95% CI)a | Yes (n = 37) | No (n = 96) | OR (95% CI)a | |||||
n | (%) | n | (%) | n | (%) | n | (%) | |||
DPYS-rs2298840 | ||||||||||
GG | 80 | (97.6) | 96 | (100) | Ref | 36 | (97.3) | 96 | (100) | Ref |
GA | 2 | (2.4) | 0 | (0.0) | – | 1 | (2.7) | 0 | (0.0) | – |
|  | Fisher’s exact test: P = 0.211 |  | Fisher’s exact test: P = 0.278 |  | ||||||
DPYS-rs143004875 | ||||||||||
-/- | 74 | (90.2) | 96 | (100) | Ref | 33 | (89.9) | 96 | (100) | Ref |
-/T | 8 | (9.8) | 0 | (0.0) | – | 4 | (10.8) | 0 | (0.0) | – |
|  | Fisher’s exact test: P = 0.002 |  | Fisher’s exact test: P = 0.005 |  | ||||||
PPARD-rs2016520 | ||||||||||
CC | 28 | (34.2) | 59 | (61.5) | Ref | 8 | (21.6) | 59 | (61.5) | Ref |
CT | 22 | (26.8) | 18 | (18.8) | 2.60 (1.14–5.87) | 14 | (37.8) | 18 | (18.8) | 6.54 (2.16–19.80) |
TT | 32 | (39.0) | 19 | (19.8) | 3.54 (1.66–7.56) | 15 | (40.5) | 19 | (19.8) | 5.96 (2.06–17.20) |
|  | Fisher’s exact test: P = 0.001 |  | Fisher’s exact test: P = 0.0001 |  | ||||||
PPARD-rs9658170 | ||||||||||
GG | 80 | (97.6) | 93 | (96.9) | Ref | 36 | (97.3) | 93 | (96.9) | Ref |
GA | 2 | (2.4) | 3 | (3.1) | 0.52 (0.07–4.09) | 1 | (2.7) | 3 | (3.1) | 0.37 (0.03–5.05) |
|  | Fisher’s exact test: P = 1.000 |  | Fisher’s exact test: P = 1.000 |  | ||||||
PPARD-rs9658167 | ||||||||||
GG | 79 | (96.3) | 93 | (96.9) | Ref | 35 | (94.6) | 93 | (96.9) | Ref |
GA | 3 | (3.7) | 3 | (3.1) | 1.75 (0.32–9.43) | 2 | (5.4) | 3 | (3.1) | 3.57 (0.49–26.19) |
|  | Fisher’s exact test: P = 1.000 |  | Fisher’s exact test: P = 0.618 |  | ||||||