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Table 1 Estimated causal effect of very severe COVID-19 on CHD susceptibility

From: Identification of genetic loci jointly influencing COVID-19 and coronary heart diseases

MR method

Interpretation

OR

95% CI

P value

Inverse variance weighted

Primary resulta

1.01

1.01–1.02

2.20E−14

MR Egger

Regression estimatea

1.03

1.02–1.04

1.68E−07

Intercept

Intercept test for pleiotropyb

0.01

− 0.057 to 0.063

9.42E−01

Weighted median

Consistencya

1.00

0.99–1.01

5.56E−02

Simple mode

Consistencya

1.04

1.03–1.05

1.48E−06

  1. MR Mendelian randomization, OR odds ratio, CI confidence interval
  2. aUnit: the estimated odds ratio for CHD per 1‐unit log odds increase in liability to very severe COVID-19
  3. bUnit: average pleiotropic effect of a COVID-19 genetic variant on the odds of CHD