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Table 3 Bayesian colocalization suggested the shared causal SNPs between COVID-19 and CHD susceptibility

From: Identification of genetic loci jointly influencing COVID-19 and coronary heart diseases

SNP

Closest gene

CHRPOSb

Ref Allele

Alt Allele

MAFc

PP4d

P_Covid-19

B_Covid-19

P_CHD

B_CHD

aCovid 19_A

 rs10490770

LZTFL1

3:45864732

T

C

0.10

0.71

8.96E−45

0.62

0.21

0.71

 rs17713054

LZTFL1

3:45859651

G

A

0.11

0.69

1.47E−44

0.62

0.36

0.82

  1. aCOVID-19_A is defined as very severe respiratory confirmed COVID-19 versus the general population
  2. bCHRPOS is mapped in Hg19 (GRCh37)
  3. cMAF, minor allele frequency, is estimated among individuals of European ancestry within CHD datasets
  4. dPP4 is the posterior probability of a single causal SNP common to COVID-19 and CHD in the test region
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Human Genomics

ISSN: 1479-7364