Identification of genetic loci jointly influencing COVID-19 and coronary heart diseases

Table 4 The conjunction false discovery rate (conjFDR) suggested evidence for the shared causal SNPs between COVID-19 and CHD susceptibility

SNP	Closest gene	CHRPOS^d	Ref Allele	Alt Allele	Z Score		Conjunctional false discovery rate	P value
SNP	Closest gene	CHRPOS^d	Ref Allele	Alt Allele	Covid 19	CHD	Conjunctional false discovery rate	Covid 19	CHD
^aCovid 19_A
rs579459	ABO	9: 136154168	C	T	4.14	5.17	6.61E−03	3.47E−05	2.30E−07
rs495828	ABO	9: 136154867	T	G	4.48	5.11	1.48E−03	7.52E−06	3.18E−07
^bCovid 19_B
rs579459	ABO	9: 136154168	C	T	4.88	5.17	1.84E−04	1.04E−06	2.31E−07
rs495828	ABO	9: 136154867	T	G	5.16	5.11	4.31E−05	2.41E−07	3.19E−07
rs2744961	ILRUN	6:34655000	T	C	3.64	3.64	4.34E−02	2.67E−04	2.67E−04
^cCovid 19_C
rs579459	ABO	9: 136154168	C	T	8.13	5.18	2.43E−05	4.31E−16	2.24E−07
rs495828	ABO	9: 136154867	T	G	7.89	5.12	3.27E−05	2.94E−15	3.10E−07
rs4962153	CACFD1	9:136323754	A	G	4.00	3.83	1.17E−02	6.22E−05	1.30E−04
rs3094379	CACFD1	9:136334910	T	C	3.95	4.11	8.43E−03	7.69E−05	3.97E−05

^aCOVID-19_A is defined as very severe respiratory confirmed COVID-19 versus the general population
^bCOVID-19_B is defined as hospitalization for COVID-19 versus the general population
^cCOVID-19_C is defined as a positive COVID-19 diagnosis versus the general population
^dCHRPOS is mapped in Hg19 (GRCh37)

ISSN: 1479-7364