Fig. 1
From: Phenome-wide association study on miRNA-related sequence variants: the UK Biobank
Study overview. We conducted PheWAS on variants in miRNAs using the UK Biobank data (N = 423,419). Putative target genes for miRNAs with FDR-significant findings in their seed regions were identified by leveraging databases for target genes of miRNAs and the genome-wide association studies (GWAS) hits for relevant traits. Further, we tested whether changes in miRNA expression could affect disease risk through colocalisation and Mendelian randomisation