Phenome-wide association study on miRNA-related sequence variants: the UK Biobank

Table 3 Mendelian randomisation analysis

SNP	EA	Exposure	SNP-miRNA association			SNP-outcome association				miRNA-outcome association
SNP	EA	Exposure	Beta	SE	P	Outcome	Beta	SE	P	Beta	SE	P
Outcome data from the UK Biobank
rs2276448	T	miR-6891-3p	0.13	0.03	2.39 × 10^–6	Hyperlipidemia	− 0.046	0.011	1.01 × 10^–5	− 0.37	0.08	1.01 × 10^–5
Outcome data from GLGC
rs2276448	T	miR-6891-3p	0.13	0.03	2.39 × 10^–6	HDL-C	− 0.003	0.002	1.42 × 10^–1	− 0.02	0.02	1.42 × 10^–1
						TG	− 0.010	0.002	6.46 × 10^–7	− 0.08	0.02	6.46 × 10^–7
						TC	− 0.019	0.002	4.79 × 10^–24	− 0.15	0.01	4.79 × 10^–24
						LDL-C	− 0.017	0.002	2.87 × 10^–19	− 0.14	0.02	2.87 × 10^–19
						Non-HDL-C	− 0.018	0.002	4.51 × 10^–14	− 0.14	0.02	4.51 × 10^–14

EA effect allele, SE standard error, GLGC global lipid genetics consortium, TC total cholesterol, TG triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, MR analysis was conducted using Wald ratio method

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