Table 6 Performance of MmisP and other tools under recommended thresholds
Methods | MmisP | M-CAP | REVEL |
|---|---|---|---|
Overall accuracy (%) | 56.74 | 52.19 | 52.54 |
The proportion of variants classified with recommended (%) | 61.12 | 65.5 | 55.0 |
Accuracy of recommended classifications (%) | 92.84 | 79.68 | 94.54 |
The proportion of variants with indeterminate classification (%) | 38.88 | 34.5 | 45.0 |
Recall (%) | 97.81* | 41.67 | 98.39 |
Precision (%) | 89.5 | 89.28 | 94.35 |
Specificity (%) | 87.35 | 97.64 | 91.34 |
NPV (%) | 97.32 | 77.99 | 97.48 |