Fig. 4
From: SPP1 is associated with adverse prognosis and predicts immunotherapy efficacy in penile cancer
SPP1 expression in PSCC and pan-cancer. A Comparison of the expression of SPP1 between PSCC and matched normal tissues in 8 paired tissues. B Comparison of SPP1 expression between LM and matched normal tissues in 8 paired tissues. C Pan-cancer differential expression of SPP1 was mostly upregulated in cancer tissues compared to normal controls from the TCGA database. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001. D Immunohistochemical staining for SPP1 in PSCC tissues. The standard staining intensity score of SPP1 in the cytoplasm was Intensity = 0 for no staining, Intensity = 1 for weak staining, Intensity = 2 for clear staining and Intensity = 3 for strong staining. E The SPP1 gene was significantly associated with B cell, CD8 + T cell, CD4 + T cell, macrophage, neutrophil and dendritic cell infiltration in four types of cancers. BLCA = bladder cancer, COAD = colon adenocarcinoma, GBM = glioblastoma, HNSC = head and neck squamous cell carcinoma