Fig. 1

Heat maps illustrating expression profile of circRNA and its biological properties. a Heat map illustrates normalized expression values of significantly expressed circRNAs in cancer tissues with log2FC ≥ 0.585, P value cut-off ≤ 0.05, q-value cut-off ≤ 1.00. Each column represents one tissue sample. Red represents upregulated and green represents downregulated circRNAs. b Scatter plot illustrates differentially expressed circRNAs in cancer tissues. c Volcano graph illustrates differentially expressed circRNAs in cancer tissues with log2 fold change. d Heat map illustrates normalized expression values of significantly expressed circRNAs in cancer adjacent tissues with log2FC ≥ 0.585, p-value cut-off ≤ 0.05, q-value cut-off ≤ 1.00. Each column represents one tissue sample. Red represents upregulated and green represents downregulated circRNAs. e Volcano graph illustrates differentially expressed circRNAs in cancer adjacent tissues with log2 fold change. f hsa_circ_0032746 characterization figure. hsa_circ_0032746 is back-spliced by exons 1 and 4. Back splice junction obtained by Sanger sequencing. The chromosomal location of hsa_circ_0032746