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Fig. 10 | Human Genomics

Fig. 10

From: Protein–protein interaction network-based integration of GWAS and functional data for blood pressure regulation analysis

Fig. 10

The BP-proteins in the KEGG-defined adrenergic signaling in cardiomyocytes pathway and their PPI network. The BP-proteins are shown (A) in the context of the KEGG pathway map, (B) with their gene symbols in respect to the numbered pathway map node symbols, and (C) in their subnetwork in the GWAS-RbSP protein interactome. BP-proteins in (C) are denoted by the number of the associated pathway map node. The color code in (A–C) indicates the protein-type (BN, GN, YN) as explained in Fig. 8. The prioritized BP-proteins are denoted with an asterisk in (B). Τhe proteins that are antihypertensive drug targets are indicated with a red eclipse in (A) and by their UniProt entry name in (C); the number of the targeting drugs is shown in parenthesis (Additional file 4)

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Human Genomics

ISSN: 1479-7364