Table 6 The BP-enriched KEGG pathways

1

hsa05200 Pathways in cancer

189

1.1E−30

31

hsa05218 Melanoma

36

1.4E−06

61

hsa04360 Axon guidance

66

3.2E−04

2

hsa05215 Prostate cancer

61

6.3E−20

32

hsa04110 Cell cycle

50

1.4E−06

62

hsa05230 Central carbon metabolism in cancer

29

4.6E−04

3

hsa04151 PI3K-Akt signaling pathway

136

8.6E−18

33

hsa04390 Hippo signaling pathway

57

1.5E−06

63

hsa05168 Herpes simplex virus 1 infection

86

5.1E−04

4

hsa05203 Viral carcinogenesis

86

1.8E−14

34

hsa04066 HIF-1 signaling pathway

43

2.1E−06

64

hsa05160 Hepatitis C

60

5.2E−04

5

hsa04520 Adherens junction

45

1.4E−13

35

hsa05211 Renal cell carcinoma

34

2.9E−06

65

hsa04310 Wnt signaling pathway

52

1.7E−03

6

hsa04915 Estrogen signaling pathway

66

2.9E−13

36

hsa04921 Oxytocin signaling pathway

61

3.5E−06

66

hsa04370 VEGF signaling pathway

27

2.2E−03

7

hsa04540 Gap junction

51

7.3E−13

37

hsa04071 Sphingolipid signaling pathway

48

4.3E−06

67

hsa04668 TNF signaling pathway

39

2.6E−03

8

hsa05166 Human T cell leukemia virus 1 infection

109

1.0E−12

38

hsa04014 Ras signaling pathway

77

6.3E−06

68

hsa05219 Bladder cancer

21

2.7E−03

9

hsa04068 FoxO signaling pathway

62

5.7E−12

39

hsa04810 Regulation of actin cytoskeleton

72

7.6E−06

69

hsa04660 T cell receptor signaling pathway

39

3.3E−03

10

hsa04015 Rap1 signaling pathway

89

6.2E−12

40

hsa05213 Endometrial cancer

30

7.9E−06

70

hsa04920 Adipocytokine signaling pathway

29

4.1E−03

11

hsa04010 MAPK signaling pathway

109

7.2E−12

41

hsa04261 Adrenergic signaling in cardiomyocytes

58

9.8E−06

71

hsa05100 Bacterial invasion of epithelial cells

31

4.8E−03

12

hsa05161 Hepatitis B

71

7.5E−12

42

hsa05210 Colorectal cancer

41

9.9E−06

72

hsa04062 Chemokine signaling pathway

59

5.0E−03

13

hsa04510 Focal adhesion

84

1.9E−11

43

hsa05223 Non−small cell lung cancer

35

1.2E−05

73

hsa04914 Progesterone−mediated oocyte maturation

34

7.0E−03

14

hsa04022 cGMP-PKG signaling pathway

72

1.9E−11

44

hsa05231 Choline metabolism in cancer

42

1.3E−05

74

hsa04666 Fc gamma R-mediated phagocytosis

33

9.0E−03

15

hsa05220 Chronic myeloid leukemia

43

8.6E−11

45

hsa05202 Transcriptional misregulation in cancer

61

1.3E−05

75

hsa04911 Insulin secretion

34

1.2E−02

16

hsa05205 Proteoglycans in cancer

80

1.1E−10

46

hsa04550 Signaling pathways regulating pluripotency of stem cells

53

1.7E−05

76

hsa04720 Long-term potentiation

29

1.3E−02

17

hsa04919 Thyroid hormone signaling pathway

56

2.0E−10

47

hsa04730 Long-term depression

32

1.8E−05

77

hsa04918 Thyroid hormone synthesis

30

1.4E−02

18

hsa04725 Cholinergic synapse

51

3.0E−09

48

hsa05414 Dilated cardiomyopathy (DCM)

43

1.9E−05

78

hsa05145 Toxoplasmosis

39

1.5E−02

19

hsa04024 cAMP signaling pathway

82

5.9E−09

49

hsa04925 Aldosterone synthesis and secretion

47

2.3E−05

79

hsa04380 Osteoclast differentiation

43

1.5E−02

20

hsa05214 Glioma

39

1.1E−08

50

hsa04924 Renin secretion

37

2.5E−05

80

hsa04020 Calcium signaling pathway

60

1.5E−02

21

hsa04120 Ubiquitin mediated proteolysis

60

6.3E−08

51

hsa05410 Hypertrophic cardiomyopathy (HCM)

40

2.9E−05

81

hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)

30

1.8E−02

22

hsa05221 Acute myeloid leukemia

33

6.7E−08

52

hsa04916 Melanogenesis

45

3.2E−05

82

hsa04917 Prolactin signaling pathway

29

1.9E−02

23

hsa05222 Small cell lung cancer

43

9.1E−08

53

hsa04931 Insulin resistance

45

3.8E−05

83

hsa04922 Glucagon signaling pathway

40

2.0E−02

24

hsa04728 Dopaminergic synapse

59

1.3E−07

54

hsa04350 TGF-beta signaling pathway

38

7.2E−05

84

hsa04664 Fc epsilon RI signaling pathway

28

2.4E−02

25

hsa04012 ErbB signaling pathway

41

2.2E−07

55

hsa04114 Oocyte meiosis

46

9.6E−05

85

hsa04270 Vascular smooth muscle contraction

48

2.8E−02

26

hsa05212 Pancreatic cancer

37

3.5E−07

56

hsa05142 Chagas disease (American trypanosomiasis)

43

1.2E−04

86

hsa05130 Pathogenic Escherichia coli infection

64

4.1E−02

27

hsa05169 Epstein–Barr virus infection

68

7.2E−07

57

hsa04662 B cell receptor signaling pathway

32

2.1E−04

87

hsa04750 Inflammatory mediator regulation of TRP channels

38

4.3E−02

28

hsa05216 Thyroid cancer

23

7.9E−07

58

hsa04713 Circadian entrainment

42

2.4E−04

29

hsa04912 GnRH signaling pathway

46

1.2E−06

59

hsa04144 Endocytosis

75

2.9E−04

hsa01100 Metabolic pathways

140

1.00 + 02

30

hsa04722 Neurotrophin signaling pathway

51

1.3E−06

60

hsa04710 Circadian rhythm

19

3.0E−04