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Fig. 1 | Human Genomics

Fig. 1

From: The diversity and clinical implications of genetic variants influencing clopidogrel bioactivation and response in the Emirati population

Fig. 1

Pathway involved in clopidogrel transport, activation, and function. When clopidogrel is administered orally as a prodrug, the medication must be absorbed within the intestine, activated by two enzymatic steps in the liver, and finally bound to the platelets receptor to exert its biological action. The ABCB1gene plays a vital role in regulating the absorption of clopidogrel. Afterward, the metabolic oxidation process is facilitated via CYP2C19 and PON1 isoenzymes in the liver to form the active thiol metabolite, which must bind to the P2Y12R receptor to exert its bioactivity (diagram created by BioRender)

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Human Genomics

ISSN: 1479-7364