Fig. 1
From: A genomics perspective of personalized prevention and management of obesity
Pathways and therapies predicted to underpin the effects of genetic variants on macronutrient responses in individuals with obesity. A The gene names associated with 313 SNPs reported to guide macronutrient intake (carbs, fat, protein and fiber; Additional file 1: Table S2) were analyzed against KEGG, WikiPathways and REACTOME (REAC) combined through the FLAME interface (https://bib.fleming.gr:8084/app/flame). The 15 most enriched pathways (based on − log10 P values) from these databases are shown in the bar chart, and 10 of them were plotted as pathways versus genes to show their interconnections. B The gene list was analyzed against the DRUGBANK database (https://go.drugbank.com/) through FLAME. Drugs and other therapies (purple stars) predicted to mostly associate with this gene set are plotted in relation to target genes