Skip to main content
Fig. 1 | Human Genomics

Fig. 1

From: Association of the C allele of rs479200 in the EGLN1 gene with COVID-19 severity in Indian population: a novel finding

Fig. 1

Schematic representation of the interplay between HIF-α and 2ODD (product of the EGLN1 gene), inhibition of HRE activation under normoxic conditions (a) and activation of HRE via dimerization with HIF-β under hypoxic conditions (b). The postulated effect of the T-allele (c) in COVID-19 hypoxia weakening HRE activation and the effect of the C allele (d) in heightened HRE activation. (Created by BioRender trial version). (2ODD- 2-oxoglutarate-dependent dioxygenase; HIF-α- Hypoxia inducible factor- α; HIF-β- Hypoxia inducible factor- β; HRE- Hypoxic response elements.)

Back to article page

Human Genomics

ISSN: 1479-7364