Fig. 4
From: Evolutionary origin of germline pathogenic variants in human DNA mismatch repair genes
Comparison for the distribution of human MMR PVs, BVs and VUS variants in non-human vertebrates. X-axis: sorted species based on the phylogenetic tree (human on the left side of the X-axis); Y-axis: the number of MMR variants shared between human and non-human vertebrates. The number of shared PVs, VUS and BVs was compared in each gene (Adjusted P < 0.0001 in MLH1, MSH2, MSH6 and PMS2, two-tailed Kruskal–Wallis test with Benjamini–Hochberg correction)