Table 2 Associations of the selected SNPs with PDAC risk
rsID | Locus | EA | NEA | EUR_freq | PanScan/PanC4 | East Asian GWAS | PANDoRA | Overall meta-analysis | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
p value | OR [95%-CI] | p value | OR [95%-CI] | p value | OR [95%-CI] | p value | OR [95%-CI] | |||||
rs10025845 | 4p14 | A | G | 0.41 | 3.76 × 10−4 | 1.08 [1.03; 1.13] | 3.43 × 10−2 | 1.09 [1.00; 1.18] | 2.00 × 10−2 | 1.08 [1.01; 1.16] | 1.32 × 10−5 | 1.08 [1.05; 1.12] |
rs11241697 | 5q23.2 | C | T | 0.41 | 2.46 × 10−4 | 0.91 [0.87; 0.96] | 4.68 × 10−3 | 0.89 [0.89; 0.96] | 1.54 × 10−1 | 1.08 [0.96; 1.22] | 3.67 × 10−1 | 0.95 [0.83; 1.06] |
rs2472632 | 11p14.1 | A | C | 0.36 | 4.35 × 10−6 | 1.11 [1.06; 1.16] | 2.01 × 10−1 | 1.05 [0.97; 1.13] | 1.00 × 10−3 | 1.13 [1.05; 1.21] | 5.52 × 10−8 | 1.10 [1.06; 1.13] |
rs11032793 | 11p13 | C | T | 0.1 | 4.27 × 10−5 | 1.17 [1.08; 1.26] | 3.77 × 10−2 | 1.37 [1.01; 1.85] | 5.23 × 10−1 | 0.97 [0.91; 1.04] | 2.69 × 10−1 | 1.10 [0.93; 1.27] |
rs17358295 | 11p13 | G | T | 0.11 | 1.64 × 10−5 | 1.17 [1.09; 1.25] | 4.60 × 10−3 | 1.47 [1.13; 1.93] | 1.10 × 10−1 | 1.09 [0.97; 1.22] | 6.10 × 10−7 | 1.16 [1.10; 1.22] |
rs11624002 | 14q32.2 | T | C | 0.16 | 8.20 × 10−5 | 1.13 [1.06; 1.20] | 1.84 × 10−1 | 1.07 [0.96; 1.19] | 4.94 × 10−1 | 1.03 [0.94; 1.13] | 1.04 × 10−4 | 1.09 [1.04; 1.14] |
rs2232079 | 20p12.3 | T | C | 0.11 | 5.31 × 10−4 | 0.87 [0.81; 0.94] | 3.94 × 10−2 | 0.83 [0.69; 0.99] | 4.00 × 10−1 | 0.94 [0.83; 1.07] | 6.38 × 10−6 | 0.88 [0.83; 0.93] |