Altered expression of serum lncRNA CASC2 and miRNA-21-5p in COVID-19 patients

Ayoub, Shymaa E.; Shaker, Olfat G.; Masoud, Mohamed; Hassan, Essam A.; Ezzat, Eman M.; Ahmed, Mona I.; Ahmed, Randa I.; Amin, Amal A. Ibrahim; Abd El Reheem, Fadwa; Khalefa, Abeer A.; Mahmoud, Rania H.

doi:10.1186/s40246-024-00578-9

Human Genomics

Table 3 Relation between clinical data and biomarkers

From: Altered expression of serum lncRNA CASC2 and miRNA-21-5p in COVID-19 patients

	CASC2			P-value	MiRNA-21 (log2)			P-value
	Median	IQR		P-value	Median	IQR		P-value
Sex
Female	0.67	0.23	0.94	0.676	8.45	5.5	10.15	0.621
Male	0.7	0.37	1	0.676	7.93	3.88	9.92	0.621
ICU admission
No	0.85	0.58	1	0.214	8.93	5.71	10.15	0.265
Yes	0.57	0.26	0.9	0.214	7.93	4.58	9.19	0.265
DM
No	0.85	0.57	1	0.303	7.93	5.06	8.84	0.551
Yes	0.64	0.25	0.96	0.303	8.2	4.82	10.17	0.551
Hypertension
No	0.84	0.38	1.07	0.073	7.06	2.74	9.92	0.246
Yes	0.6	0.23	0.89	0.073	8.06	5.5	10.3	0.246
CHD
No	0.68	0.26	0.96	0.691	7.93	4.82	10.03	0.268
Yes	0.85	0.35	1.1	0.691	8.84	8.04	14.24	0.268
CKD
CKD on HD	0.65	0.26	0.8	0.663	2.63	1.82	9.19	0.268
No	0.71	0.3	0.99	0.663	8.05	5.06	10.15	0.268
Ventilation
1 (PEEP)	0.6	0.13	0.97	0.197	8.84	6.03	10.15	0.010* 1 vs 3 3 vs 4
2 (mask)	0.82	0.37	0.94		5.71	5.06	9.92
3 (CPAP)	1.45	0.83	1.56		1.71	1.38	2.33
4 (mechanical)	0.45	0.35	0.9		8.84	5.78	10.42
GGO
Yes	0.71	0.31	0.96	0.691	7.93	4.82	10.03	0.251
No	0.6	0.1	1	0.691	9.92	8.06	10.3	0.251
Peripheral patches
Yes	0.89	0.6	1	0.701	8.95	8.06	9.92	0.284
No	0.68	0.26	0.94	0.701	7.93	4.58	10.15	0.284
Ivermectin
No	0.68	0.35	0.97	0.468	7.93	4.58	10.15	0.206
Yes	0.7	0.15	0.8	0.468	8.9	8.84	9.92	0.206
Remedesevir
No	0.8	0.32	1	0.222	7.06	4.23	10.03	0.368
Yes	0.58	0.15	0.85	0.222	8.84	5.5	10.15	0.368
Favipiravir
No	0.71	0.35	0.97	0.078	7.99	5.06	9.92	0.118
Yes	0.09	0.09	0.09	0.078	12.23	12.23	12.23	0.118
Ribavirin
No	0.71	0.35	0.97	0.196	8.05	5.06	10.15	0.667
Yes	0.13	0.13	0.13	0.196	5.5	5.5	5.5	0.667
First PCR
Negative	0.38	0.23	1	0.443	8.84	6.2	9.92	0.400
Positive	0.71	0.37	0.94	0.443	7.93	3.88	10.15	0.400
RSNA
Atypical	0.24	0.24	0.24	0.506	5.71	5.71	5.71	0.621
Undetermined	0.26	0.23	1		5.58	2.63	9.92
Typical	0.71	0.37	0.9		8.59	5.06	10.15
CXR18 (0–18)
Mild	0.76	0.4	0.95	0.342	5.52	3.31	8.2	0.009* Mild vs Severe
Moderate	0.7	0.35	1.07		8.84	5.26	10.15
Severe	0.45	0.23	0.8		10.56	9.19	10.69
TSS total score (0–20)
None	0.24	0.24	0.24	0.462	5.71	5.71	5.71	0.540
Mild	0.80	0.37	1.00		6.20	4.58	9.92
Moderate	0.65	0.35	0.94		8.84	5.06	10.15

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