Table 1 Effect of CYP2D6 phenotype on plasma solanidine and metabolite to solanidine ratios in healthy volunteers (n = 314)
From: Solanidine is a sensitive and specific dietary biomarker for CYP2D6 activity
Phenotype (n) | Geometric mean (95% CI) | Ratio to normal function (95% CI) | P |
|---|---|---|---|
Feature: Solanidine (ng/mL) | |||
Poor metabolizer (9) | 1.76 (0.775, 4.02) | 19.9 (8.55, 46.1) | 1.88 × 10–11 |
Intermediate metabolizer (89) | 0.154 (0.119, 0.200) | 1.74 (1.27, 2.38) | 6.40 × 10–4 |
Normal metabolizer (196) | 0.0889 (0.0746, 0.106) | 1.00 | |
Ultrarapid metabolizer (20) | 0.0580 (0.0333, 0.101) | 0.653 (0.364, 1.17) | 0.151 |
Feature: m/z 414 to solanidine peak area ratio | |||
Poor metabolizer (9) | 0.00649 (0.00441, 0.00954) | 0.000863 (0.000582, 0.00128) | 1.31 × 10–109 |
Intermediate metabolizer (89) | 5.49 (4.86, 6.20) | 0.731 (0.630, 0.845) | 3.75 × 10–5 |
Normal metabolizer (196) | 7.52 (6.92, 8.16) | 1.00 | |
Ultrarapid metabolizer (20) | 7.20 (5.55, 9.34) | 0.958 (0.729, 1.26) | 0.758 |
Feature: m/z 416 to solanidine peak area ratio | |||
Poor metabolizer (9) | 0.00433 (0.00231, 0.00811) | 0.000765 (0.000402, 0.00146) | 6.84 × 10–65 |
Intermediate metabolizer (89) | 3.08 (2.53, 3.76) | 0.545 (0.429, 0.693) | 1.11 × 10–6 |
Normal metabolizer (196) | 5.65 (4.95, 6.47) | 1.00 | |
Ultrarapid metabolizer (20) | 7.99 (5.23, 12.2) | 1.41 (0.905, 2.20) | 0.128 |
Feature: m/z 444 to solanidine peak area ratio | |||
Poor metabolizer (9) | 0.00319 (0.00157, 0.00648) | 0.00280 (0.00135, 0.00579) | 5.23 × 10–42 |
Intermediate metabolizer (89) | 0.382 (0.305, 0.479) | 0.335 (0.256, 0.440) | 4.46 × 10–14 |
Normal metabolizer (196) | 1.14 (0.979, 1.33) | 1.00 | |
Ultrarapid metabolizer (20) | 2.29 (1.42, 3.69) | 2.01 (1.21, 3.32) | 0.00682 |
Feature: m/z 430 to solanidine peak area ratio | |||
Poor metabolizer (9) | 0.00420 (0.00217, 0.00816) | 0.00406 (0.00206, 0.00801) | 3.48 × 10–42 |
Intermediate metabolizer (89) | 0.347 (0.281, 0.428) | 0.335 (0.260, 0.432) | 9.73 × 10–16 |
Normal metabolizer (196) | 1.04 (0.899, 1.19) | 1.00 | |
Ultrarapid metabolizer (20) | 2.15 (1.38, 3.37) | 2.08 (1.30, 3.33) | 0.00234 |
Feature: m/z 412 to solanidine peak area ratio | |||
Poor metabolizer (9) | 0.00331 (0.00208, 0.00527) | 0.0140 (0.00869, 0.0225) | 1.22 × 10–48 |
Intermediate metabolizer (89) | 0.152 (0.131, 0.177) | 0.644 (0.539, 0.769) | 1.80 × 10–6 |
Normal metabolizer (196) | 0.236 (0.214, 0.261) | 1.00 | |
Ultrarapid metabolizer (20) | 0.345 (0.252, 0.473) | 1.460 (1.05, 2.03) | 0.0245 |