Fig. 4
From: Meta-analysis of 46,000 germline de novo mutations linked to human inherited disease
Comparison of predicted deleteriousness of two groups of HGMD disease-causing missense mutations (5,307 DNM versus 32,605 non-DNM) (A). A purple bar indicates the proportion of dataset overlap between DNM and non-DNM for a specific range of CADD scores. The colour of the remaining stacked bar indicates an enrichment of a specific dataset at a specific CADD score; thus, red indicates enrichment of the DNM set whereas blue denotes enrichment of the non-DNM set (B)