Table 2 Biological processes for 187 genes enriched in DNMs
From: Meta-analysis of 46,000 germline de novo mutations linked to human inherited disease
Gene Ontology Term | Number of genes | Fold enrichment | P value | FDR |
|---|---|---|---|---|
GO:0048731 system development | 124 | 2.548578 | 3.01E-31 | 9.52E-28 |
GO:0007275 multicellular organism development | 128 | 2.449113 | 4.52E-31 | 9.52E-28 |
GO:0007399 nervous system development | 89 | 3.659853 | 1.31E-30 | 1.84E-27 |
GO:0044707 single-multicellular organism process | 136 | 2.152079 | 3.94E-28 | 4.15E-25 |
GO:0048856 anatomical structure development | 130 | 2.234834 | 1.25E-27 | 1.01E-24 |
GO:0045893 positive regulation of transcription, DNA-templated | 71 | 4.31298 | 1.68E-27 | 1.01E-24 |
GO:1,903,508 positive regulation of nucleic acid-templated transcription | 71 | 4.31298 | 1.68E-27 | 1.01E-24 |
GO:1,902,680 positive regulation of RNA biosynthetic process | 71 | 4.290988 | 2.28E-27 | 1.19E-24 |
GO:0044767 single-organism developmental process | 134 | 2.150094 | 2.53E-27 | 1.19E-24 |
GO:0010628 positive regulation of gene expression | 79 | 3.696033 | 1.05E-26 | 4.43E-24 |