Table 1 Two-sample MR result: the causal effect of depression, bipolar disorder, anxiety disorders, schizophrenia, and hemorrhoidal Disease
Exposure | Outcome | Method | N(snp) | β | se | pval | OR (95%CI) | Heterogeneity P value | Intercept p value |
|---|---|---|---|---|---|---|---|---|---|
Anxiety disorders | Hemorrhoidal Disease | MR Egger | 6 | 0.051 | 0.243 | 0.844 | 1.052(0.653–1.696) | 0.006 | 0.295 |
Anxiety disorders | Hemorrhoidal Disease | Weighted median | 6 | 0.042 | 0.057 | 0.459 | 1.043(0.933–1.165) | Na | Na |
Anxiety disorders | Hemorrhoidal Disease | Inverse variance weighted | 6 | 0.027 | 0.047 | 0.563 | 1.027(0.937–1.126) | 0.003 | Na |
Anxiety disorders | Hemorrhoidal Disease | Simple mode | 6 | 0.045 | 0.064 | 0.511 | 1.046(0.923–1.185) | Na | Na |
Anxiety disorders | Hemorrhoidal Disease | Weighted mode | 6 | 0.042 | 0.054 | 0.469 | 1.043(0.938–1.160) | Na | Na |
Bipolar disorder | Hemorrhoidal Disease | MR Egger | 44 | -0.035 | 0.124 | 0.776 | 0.965(0.757–1.230) | < 0.001 | 0.580 |
Bipolar disorder | Hemorrhoidal Disease | Weighted median | 44 | 0.001 | 0.017 | 0.946 | 1.001(0.968–1.036) | Na | Na |
Bipolar disorder | Hemorrhoidal Disease | Inverse variance weighted | 44 | 0.033 | 0.021 | 0.127 | 1.033(0.991–1.077) | < 0.001 | Na |
Bipolar disorder | Hemorrhoidal Disease | Simple mode | 44 | -0.026 | 0.037 | 0.494 | 0.975(0.906–1.049) | Na | Na |
Bipolar disorder | Hemorrhoidal Disease | Weighted mode | 44 | -0.026 | 0.035 | 0.466 | 0.975(0.910–1.044) | Na | Na |
Depression | Hemorrhoidal Disease | MR Egger | 37 | 0.204 | 0.176 | 0.253 | 1.226(0.869–1.730) | 0.004 | 0.911 |
Depression | Hemorrhoidal Disease | Weighted median | 37 | 0.108 | 0.064 | 0.090 | 1.114(0.983–1.262) | Na | Na |
Depression | Hemorrhoidal Disease | Inverse variance weighted | 37 | 0.185 | 0.051 | < 0.001 | 1.203(1.089–1.329) | 0.005 | Na |
Depression | Hemorrhoidal Disease | Simple mode | 37 | 0.054 | 0.145 | 0.709 | 1.056(0.795–1.402) | Na | Na |
Depression | Hemorrhoidal Disease | Weighted mode | 37 | 0.045 | 0.126 | 0.723 | 1.046(0.817–1.340) | Na | Na |
Schizophrenia | Hemorrhoidal Disease | MR Egger | 27 | -0.020 | 0.015 | 0.200 | 0.980(0.951–1.010) | 0.612 | 0.363 |
Schizophrenia | Hemorrhoidal Disease | Weighted median | 27 | -0.004 | 0.009 | 0.695 | 0.996(0.979–1.015) | Na | Na |
Schizophrenia | Hemorrhoidal Disease | Inverse variance weighted | 27 | -0.007 | 0.007 | 0.265 | 0.993(0.980–1.006) | 0.617 | Na |
Schizophrenia | Hemorrhoidal Disease | Simple mode | 27 | -0.006 | 0.017 | 0.729 | 0.994(0.962–1.027) | Na | Na |
Schizophrenia | Hemorrhoidal Disease | Weighted mode | 27 | -0.006 | 0.015 | 0.693 | 0.994(0.966–1.023) | Na | Na |
Hemorrhoidal Disease | Anxiety disorders | MR Egger | 73 | 0.078 | 0.128 | 0.545 | 1.081(0.841–1.390) | < 0.001 | 0.869 |
Hemorrhoidal Disease | Anxiety disorders | Weighted median | 73 | 0.048 | 0.053 | 0.362 | 1.049(0.946–1.163) | Na | Na |
Hemorrhoidal Disease | Anxiety disorders | Inverse variance weighted | 73 | 0.050 | 0.041 | 0.219 | 1.052(0.971–1.139) | < 0.001 | Na |
Hemorrhoidal Disease | Anxiety disorders | Simple mode | 73 | -0.041 | 0.132 | 0.759 | 0.960(0.741–1.244) | Na | Na |
Hemorrhoidal Disease | Anxiety disorders | Weighted mode | 73 | 0.056 | 0.100 | 0.577 | 1.058(0.869–1.288) | Na | Na |
Hemorrhoidal Disease | Bipolar disorder | MR Egger | 74 | -0.129 | 0.183 | 0.485 | 0.879(0.614–1.259) | < 0.001 | 0.233 |
Hemorrhoidal Disease | Bipolar disorder | Weighted median | 74 | -0.013 | 0.063 | 0.840 | 0.987(0.872–1.118) | Na | Na |
Hemorrhoidal Disease | Bipolar disorder | Inverse variance weighted | 74 | 0.080 | 0.059 | 0.178 | 1.083(0.964–1.217) | < 0.001 | Na |
Hemorrhoidal Disease | Bipolar disorder | Simple mode | 74 | -0.086 | 0.144 | 0.554 | 0.918(0.692–1.218) | Na | Na |
Hemorrhoidal Disease | Bipolar disorder | Weighted mode | 74 | -0.033 | 0.100 | 0.742 | 0.967(0.795–1.177) | Na | Na |
Hemorrhoidal Disease | Depression | MR Egger | 63 | 0.056 | 0.060 | 0.355 | 1.058(0.940–1.190) | 0.028 | 0.753 |
Hemorrhoidal Disease | Depression | Weighted median | 63 | 0.085 | 0.026 | 0.001 | 1.088(1.035–1.144) | Na | Na |
Hemorrhoidal Disease | Depression | Inverse variance weighted | 63 | 0.070 | 0.018 | < 0.001 | 1.072(1.036–1.110) | 0.034 | Na |
Hemorrhoidal Disease | Depression | Simple mode | 63 | 0.122 | 0.059 | 0.042 | 1.130(1.007–1.267) | Na | Na |
Hemorrhoidal Disease | Depression | Weighted mode | 63 | 0.096 | 0.047 | 0.045 | 1.100(1.004–1.206) | Na | Na |
Hemorrhoidal Disease | Schizophrenia | MR Egger | 75 | 0.073 | 0.395 | 0.854 | 1.076(0.496–2.334) | < 0.001 | 0.561 |
Hemorrhoidal Disease | Schizophrenia | Weighted median | 75 | -0.101 | 0.162 | 0.532 | 0.904(0.658–1.241) | Na | Na |
Hemorrhoidal Disease | Schizophrenia | Inverse variance weighted | 75 | -0.005 | 0.125 | 0.965 | 0.995(0.779–1.270) | < 0.001 | Na |
Hemorrhoidal Disease | Schizophrenia | Simple mode | 75 | -0.250 | 0.399 | 0.533 | 0.779(0.356–1.704) | Na | Na |
Hemorrhoidal Disease | Schizophrenia | Weighted mode | 75 | -0.232 | 0.327 | 0.480 | 0.793(0.418–1.505) | Na | Na |