Fig. 4

Cancer-specific promoter DNA hypermethylation in Protein Tyrosine (PTP) and Dual-Specificity Phosphatase (DUSP) are associated with gene expression silencing. A-B. Boxplots representing the effect of hypermethylated promoters of PTP genes in primary tumours (A) and cancer cell lines (B). C-D. Boxplots representing the effect of epimutations discerned in promoters of DUSP genes from primary tumours (C) and cancer cell lines (C). Primary tumour and cancer cell line gene expression data was downloaded from The Cancer Genome Atlas (TCGA) and the Cancer Cell Line Encyclopedia (CCLE) projects. Gene expression values are presented as relative units (r.u) and are specific to each project (TCGA = FPKM and CCLE = TPM). Gene names shown at the top left-hand corner of each boxplot and blue dots presents individual (and cancer cell lines) expression values where DNA methylation profiles were also available. *P < 0.05; **P < 0.01; ***P < 0.001