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Table 4 Various 3ASC models with different algorithms and features

From: Explicable prioritization of genetic variants by integration of rule-based and machine learning algorithms for diagnosis of rare Mendelian disorders

Model name

Algorithms

Data training

Bayesian score

Symptom similarity

3Cnet score

QC-related features

Inheritance pattern

3ASC (Baseline)

Multiplication

No

Yes

Yes

Yes

No

No

3ASC_LR

Logistic regression

Yes

Yes

Yes

Yes

No

No

3ASC_LR_QC

Logistic regression

Yes

Yes

Yes

Yes

Yes

No

3ASC_LR_ALL

Logistic regression

Yes

Yes

Yes

Yes

Yes

Yes

3ASC_RF

Random forest

Yes

Yes

Yes

Yes

No

No

3ASC_RF_QC

Random forest

Yes

Yes

Yes

Yes

Yes

No

3ASC_RF_ALL

Random forest

Yes

Yes

Yes

Yes

Yes

Yes