Table 1 TTR amyloidogenic mutations and matched controls from UKB. Information about ancestral background, age, sex, number of individuals carrying TTR amyloidogenic mutations (Ncarriers) and non-carriers (Nnon−carriers) for each population, and the total number of individuals are reported. AFR: African; AMR: admixed Americans; CSA: Central-South Asian; EAS: East Asian; EUR: European; MID: Middle Eastern
From: Clinical spectrum of Transthyretin amyloidogenic mutations among diverse population origins
Mutation (rsid) | Ancestry | Age, mean (SE) | Female, % | Ncarriers | Nnon−carriers |
|---|---|---|---|---|---|
Phe44Leu (rs138065384) | AFR | 58.8 (0.43) | 100 | 2 | 200 |
Ala81Thr (rs730881165) | EAS | 49 (0.32) | 28 | 4 | 400 |
EUR | 56.8 (0.12) | 55 | 347 | 3,470 | |
His90Asn (rs121918074) | CSA | 53 (0.86) | 35 | 1 | 100 |
EUR | 57 (0.14) | 53 | 33 | 3,300 | |
MID | 54.3 (0.79) | 100 | 1 | 100 | |
Val122Ile (rs76992529) | AFR | 52.8(0.15) | 54 | 266 | 2,660 |
AMR | 54.5 (0.88) | 100 | 1 | 100 | |
CSA | 59.7(0.50) | 0 | 2 | 200 | |
EUR | 52.3 (0.21) | 46 | 15 | 1,500 | |
MID | 45.9 (0.24) | 55 | 4 | 400 |