Table 2 Neurodevelopmental disorder associations for differentially methylated regions (DMRs)
Disease | Overlapping genes | Fold enrichment (odds ratio) | OR 95% confidence interval | P-Value | FDR |
|---|---|---|---|---|---|
APA Inner Cell Mass (ICM) | |||||
Autism spectrum disorder | 149/1127 | 4.30 | 3.56-5.18 | 1.0E-41* | 1.0E-40* |
Schizophrenia | 108/2092 | 1.43 | 1.16-1.76 | 8.5E-04* | 1.9E-03* |
Bipolar disorder | 21/430 | 1.32 | 0.81-2.05 | 0.20 | 0.24 |
APA Trophectoderm (TE) | |||||
Autism spectrum disorder | 150/1127 | 3.77 | 3.12-4.53 | 3.6E-36* | 3.1E-35* |
Schizophrenia | 122/2092 | 1.44 | 1.17-1.74 | 3.2E-04* | 7.8E-04* |
Bipolar disorder | 30/430 | 1.71 | 1.13-2.4 | 7.6E-03* | 1.2E-02* |