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Table 2 Numbers of C → T and G → A mutations found in CpG dinucleotides and CpHpG trinucleotides in a dataset of 1,766 regulatory mutations of 191 gene promoters (HGMD) and the numbers of possible C → T and G → A mutations in CpG dinucleotides and CpHpG trinucleotides.

From: Methylation-mediated deamination of 5-methylcytosine appears to give rise to mutations causing human inherited disease in CpNpG trinucleotides, as well as in CpG dinucleotides

Di/trinucleotide

Dataset

Number of mutations in

p-value

  

in di/trinucleotide

not in di/trinucleotide

 

CpG

HGMD

94

1,672

6.03 × 10-9

 

Possible

1,940

64,213

 

CpHpG

HGMD

54

1,712

0.011

 

Possible

2,838

63,315