Figure 2
From: The human fatty acid-binding protein family: Evolutionary divergences and functions
Phylogenetic analysis of human FABP family members. Using ClustalW alignment software of known peptide sequences for FABP1-9, FABP12, CRABP2 and LCN1, a dendogram with branch lengths was constructed. Clustering analysis showed divergence of iLBP family members by their known and established subfamilies: Subfamily I - FABP1, FABP6, Subfamily III - FABP2, Subfamily IV - FABP3, FABP4, FABP5, FABP7, FABP8, FABP9, and the newly established FABP family member FABP12. Subfamily II includes CRABP and CRBP: only CRABP2 was included in this analysis, to demonstrate similarities in the divergences of the iLBP family. Additionally, a member of the calcyin superfamily of hydrophobic ligand-binding proteins, lipocalin 1 (LCN1, GenBank accession no. NP_002288), was included in this analysis as an outgroup, as calcyins share ≤ 10 per cent homology with iLBP members.