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Table 4 Gene Ontology analysis for the 126 genes mapped to significantly differentiated genomic regions

From: Inter-chromosomal variation in the pattern of human population genetic structure

GO category

GO ID

pvalue

GO term name

Overrepresented genes

Molecular

function

GO:0005516

0.00138

Calmodulin binding

MAP6, MYH9, MYLK, DAPK1, MYO5C

Molecular

function

GO:0016462

0.001431

Pyrophosphatase activity

TGM3, ABCB7, MYH9, DYNC1LI1, DUT, MYO5C,

MCM6, ATAD3B, ZRANB3, DNAH5, ATAD3C, IQCA1

Molecular

function

GO:0016818

0.001478

Hydrolase activity,

acid anhydrides, phosphorus-

containing anhydrides

TGM3, ABCB7, MYH9, DYNC1LI1, DUT, MYO5C,

MCM6, ATAD3B, ZRANB3, DNAH5, ATAD3C, IQCA1

Molecular

function

GO:0016817

0.001509

Hydrolase activity,

acting on acid anhydrides

TGM3, ABCB7, MYH9, DYNC1LI1, DUT, MYO5C,

MCM6, ATAD3B, ZRANB3, DNAH5, ATAD3C, IQCA1

Molecular

function

GO:0003779

0.002797

Actin binding

MYH9, MYLK, MKL1, MKL2, MYO5C, SYNE2, HIP1

Biological

process

GO:0006582

0.000032

Melanin metabolic process

SLC45A2, OCA2, CITED1

Biological

process

GO:0043473

0.000574

Pigmentation

SLC45A2, OCA2, EDAR, CITED1

Biological

process

GO:0031641

0.00078

Regulation of myelination

IFNG, CDH2

Biological

process

GO:0048066

0.001018

Developmental pigmentation

SLC45A2, OCA2, CITED1

Biological

process

GO:0015701

0.001245

Bicarbonate transport

PTGER3, SLC4A5

Cellular

component

GO:0000299

0.000209

Integral to membrane

of membrane fraction

ARSA, MLC1, SEMA4F

Cellular

component

GO:0045009

0.000983

Chitosome

SLC45A2, OCA2

Cellular

component

GO:0033162

0.000983

Melanosome membrane

SLC45A2, OCA2

Cellular

component

GO:0048770

0.001653

Pigment granule

SLC45A2, OCA2, YWHAE, SLC24A5

Cellular

component

GO:0042470

0.001653

Melanosome

SLC45A2, OCA2, YWHAE, SLC24A5

  1. Abbreviations
  2. MAP6, microtubule-associated protein 6 gene; MYH9, myosin, heavy chain 9 non-muscle gene; MYLK, Myosin light chain kinase gene, MYO5C, myosin VC gene; TGM3, transglutaminase 3 gene; ABCB7, gene for ATP-binding cassette sub-family B, member 7; DYNC1L11, cytoplasmic dynein 1 light intermediate chain 11 gene; DUT , deoxyuridine 5'-triphosphate nucleotidohydrodase gene; MCM6, minichromosome maintenance complex component 6 gene; ATAD3C, AAA domain-containing 3C gene, ZRANNB3, zinc finger RAN-binding domain-containing 3 gene; DNAH5, dynein axonemal heavy chain 5 gene; ATAD3B, AAA domain-containing 3B gene; IQCAI, IQ motif containing with AAA domain gene; MKL1, megakavyoblastic leukaemia (translocation) 1 gene; MKL2, megakavyoblastic leukaemia (translocation) 2 gene; SYNE2, spectrin repeat containing nuclear envelope 2 gene; HIP1, Huntingtin interacting protein 1 gene; SLC45A2, gene for solute carrier family 45, member 2; CDH2, cadherin 2 gene; PTGER3, prostaglandin E receptor 3 (subtype EP3) gene; SLC4AS, gene for solute carrier family 4 sodium bicarbonate cotransporter member 5; ARSA, arylsulfatase 4 gene; MLC1, megalencephalic leukoencephalopathy with subcortical cysts 1 gene; SEMA4F , semaphorin 4F gene; YWHAE, 14-3-3 protein epsilon gene, CITED1 cbp/p300-interacting transactivator 1 gene; OCA2, p protein gene; EDAR, ectodysphasin A receptor gene.
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Human Genomics

ISSN: 1479-7364