Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration

Table 5 Calculation of choroidal neovascular disease risk score: $S = intercept + \sum_{i = 1}^{13} β i * X i$ , where β and X are as follows

Parameter	Regression coefficient	p-value	X	Point estimate	95% Wald confidence limits		Pr^a > Chisq
Intercept	0.7851	0.1885	1	--	--	--	--
rs10490924	1.4537	<0.0001	GG = 0, GT = 1, TT = 2	4.279	3.346	5.472	<0.0001
rs1061170	-0.7687	0.0105	CT = 1, CC = 0, TT = 2	0.464	0.257	0.835	0.0105
rs10922153	-0.6018	0.1129	GT = 1, GG = 0, TT = 2	0.548	0.26	1.153	0.1129
rs12144939	-0.1974	0.4375	GG = 0, GT = 1, TT = 2	0.821	0.499	1.351	0.4375
rs1409153	-0.1595	0.5665	AG = 1, GG = 0, AA = 2	0.853	0.494	1.471	0.5665
rs1750311	-0.1316	0.6834	CC = 0, AC = 1, AA = 2	0.877	0.466	1.65	0.6834
rs2230199	0.428	0.0009	CC = 0, CG = 1, GG = 2	1.534	1.192	1.975	0.0009
rs2274700	-0.7954	0.0002	GG = 0, AG = 1, AA = 2	0.451	0.296	0.689	0.0002
rs2990510	-0.4596	0.1358	GT = 1, TT = 0, GG = 2	0.632	0.345	1.155	0.1358
rs403846	0.8131	0.0404	AG = 1, AA = 0, GG = 2	2.255	1.036	4.906	0.0404
rs641153	-0.8243	<0.0001	CC = 0, CT = 1, TT = 2	0.439	0.295	0.651	<0.0001
rs698859	-0.015	0.9559	AG = 1, GG = 0, AA = 2	0.985	0.58	1.673	0.9559
rs9332739	-0.9544	0.0027	GG = 0, CG = 1, CC = 2	0.385	0.206	0.719	0.0027

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