Skip to main content

Table 5 Calculation of choroidal neovascular disease risk score: S = intercept + i = 1 13 β i * X i , where β and X are as follows

From: Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration

Parameter Regression
coefficient
p-value X Point
estimate
95% Wald
confidence
limits
Pra > Chisq
Intercept 0.7851 0.1885 1 -- -- -- --
rs10490924 1.4537 <0.0001 GG = 0, GT = 1, TT = 2 4.279 3.346 5.472 <0.0001
rs1061170 -0.7687 0.0105 CT = 1, CC = 0, TT = 2 0.464 0.257 0.835 0.0105
rs10922153 -0.6018 0.1129 GT = 1, GG = 0, TT = 2 0.548 0.26 1.153 0.1129
rs12144939 -0.1974 0.4375 GG = 0, GT = 1, TT = 2 0.821 0.499 1.351 0.4375
rs1409153 -0.1595 0.5665 AG = 1, GG = 0, AA = 2 0.853 0.494 1.471 0.5665
rs1750311 -0.1316 0.6834 CC = 0, AC = 1, AA = 2 0.877 0.466 1.65 0.6834
rs2230199 0.428 0.0009 CC = 0, CG = 1, GG = 2 1.534 1.192 1.975 0.0009
rs2274700 -0.7954 0.0002 GG = 0, AG = 1, AA = 2 0.451 0.296 0.689 0.0002
rs2990510 -0.4596 0.1358 GT = 1, TT = 0, GG = 2 0.632 0.345 1.155 0.1358
rs403846 0.8131 0.0404 AG = 1, AA = 0, GG = 2 2.255 1.036 4.906 0.0404
rs641153 -0.8243 <0.0001 CC = 0, CT = 1, TT = 2 0.439 0.295 0.651 <0.0001
rs698859 -0.015 0.9559 AG = 1, GG = 0, AA = 2 0.985 0.58 1.673 0.9559
rs9332739 -0.9544 0.0027 GG = 0, CG = 1, CC = 2 0.385 0.206 0.719 0.0027
  1. a The probability of risk = exp(risk score)/[1 +exp(risk score)]