Fig. 1

Overview of clonality analysis and visualization of results. The workflow consists of two main bottlenecks. In bottleneck a, our original tag system was used to isolate HTLV-1 integration sites in infected individuals and measure the size of clones. Subsequently, our in silico pipeline was used to analyze the high-throughput sequencing data. In bottleneck b, which is the main focus of this manuscript, the observed clone sizes were classified and visualized using different shapes and colors using the concept of hierarchical tree structure