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Table 6 Prediction of epidermal and hyperproliferative keratin mutation’s pathogenicity in moderate psoriasis using Alamut Visual software

From: Mutational analysis of epidermal and hyperproliferative type I keratins in mild and moderate psoriasis vulgaris patients: a possible role in the pathogenesis of psoriasis along with disease severity

S. no. MT position Exon seq.MT Type of MT AA change Variant in protein domain SIFT Mutation taster Mutation assessor
Prediction Score Range score Prediction Range score P value Prediction Score Range score
  K14               
1 388 1 C > G Missense p.(Leu130Val) IF protein Damaging 0.001 0.7842 DC 0.537 1 High 3.8199 0.9566
2 415 1 G > C Missense p.(Ala139Pro) IF protein Damaging 0.006 0.6138 DC 0.8103 1 High 4.3049 0.9832
3 419 1 A > T Missense p.(Asn140Ile) IF protein Damaging 0 0.9122 DC 0.5881 1 High 4.425 0.9876
4 442 1 C > T Missense p.(Arg148Cys) IF protein Damaging 0 0.9122 DC 0.5881 1 High 3.75 0.9513
5 512 1 A > T Missense p.(Asp171Val) IF protein Damaging 0 0.9122 DC 0.8103 1 High 3.835 0.9576
6 519 1 G > T Missense p.(Arg173Ser) IF protein Damaging 0.001 0.7842 DC 0.4122 0.991 High 4.025 0.9697
7 904 4 G > C Missense p.(Ala302Pro) IF protein, prefoldin Damaging 0.001 0.7842 Polymorphism 0.2979 0.735 High 4.085 0.9729
8 1057 6 G > C Missense p.(Ala353Pro) IF protein, keratin type I Tolerated 0.189 0.2119 DC 0.4816 0.999 High 3.875 0.9604
9 1234 6 A > T Missense p.(Ile412Phe) IF protein (conserved site), IF Damaging 0 0.9122 DC 0.8103 1 High 4.65 0.9939
  K10               
10 479 1 A > C Missense p.(Tyr160Ser) IF protein Damaging 0 0.9122 DC 0.8103 1 High 4.5549 0.9916
11 520 1 C > A Missense p.(Leu174Met) IF protein Damaging 0.001 0.7842 DC 0.8103 0.991 High 3.5099 0.9302
12 674 2 A > C Missense p.(Asp225Ala) IF protein Damaging 0 0.9122 DC 0.8103 1 High 3.9549 0.9656
13 704 2 G > T Missense p.(Arg235Met) IF protein, keratin type I Damaging 0 0.9122 DC 0.8103 0.84 High 4.2849 0.9824
14 711 2 G > T Missense p.(Lys237Asn) IF protein, keratin type I Damaging 0 0.9122 DC 0.8103 0.983 High 3.66 0.944
15 785 3 T > A Missense p.(Leu262Gln) IF protein, prefoldin, keratin I Damaging 0 0.9122 DC 0.8103 0.834 High 4.2399 0.9805
  K16               
16 410 1 C > T Missense p.(Ala137Val) IF Damaging 0.002 0.7209 Polymorphism 0.3052 0.65 Medium 3.39 0.9174
17 583 1 G > T Missense p.(Ala195Ser) IF protein, keratin type I Damaging 0.029 0.457 DC 0.4734 1 Medium 2.805 0.8202
18 589 1 C > A Missense p.(Leu197Met) IF protein, keratin type I Damaging 0.028 0.4608 DC 0.4467 0.998 Medium 2.88 0.8371
19 634 1 C > G Missense p.(Leu212Val) IF Damaging 0.009 0.5743 DC 0.4067 0.988 Medium 2.9849 0.8585
20 667 1 C > G Missense p.(Leu223Val) IF protein, keratin type I Damaging 0.001 0.7842 DC 0.4434 1 Medium 3.3 0.9406
  K17               
21 503 1 A > T Missense p.(Asp168Val) IF protein, keratin type I Damaging 0 0.9122 DC 0.8103 1 Medium 3.3 0.9473
22 662 2 A > T Missense p.(Asn221Ile) IF protein, prefoldin Damaging 0.01 0 Polymorphism 0.4721 0.999 Medium 2.605 0.7645
23 682 3 G > C Missense p.(Ala228Pro) IF protein, prefoldin Damaging 0.016 0.518 Polymorphism 0.1948 1 Medium 3.25 0.9409
24 907 4 C > T Missense p.(Leu303Phe) IF protein, prefoldin Damaging 0.03 0, 0.001 Polymorphism 0.5164 1 Medium 3.4749 0.9267
26 986 5 C > T Missense p.(Ala329Val) IF protein Damaging 0.51 0.017 Polymorphism 0.4593 0.999 Medium 3.17 0.8891
26 1070 5 G > T Missense p.(Arg357Leu) IF protein, keratin type I Damaging 0 0.9122 DC 0.8103 1 Medium 3.17 0.9796
27 1144 6 G > T Missense p.(Ala382Ser) IF protein (conserved site), IF Tolerated 0 0.122 Polymorphism 0.4437 0.998 Medium 2.265 0.6465
28 1210 6 A > C Missense p.(Thr404Pro) IF protein (conserved site), IF Tolerated 0 0.075 Polymorphism 0.5199 1 Medium 2.6099 0.7658
  1. DC disease causing, IF intermediate filament, MT mutation, AA amino acid